UBE2W and UBA1

Number of citations of the paper that reports this interaction (PMID 17597759)
66

Data Source:
BioGRID (pull down)

		UBE2W	UBA1
Gene Name		ubiquitin-conjugating enzyme E2W (putative)	ubiquitin-like modifier activating enzyme 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Heterochromatin Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	DNA Repair Protein Monoubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Modification-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		69 interactors: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MARCH3 MARCH5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF185 RNF2 RNF26 RNF4 RNF5 RNF8 ROPN1 STUB1 TOPORS TRIM17 TRIM2 TRIM27 TRIM31 TRIM35 TRIM39 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4	39 interactors: BUB3 CDC34 CDK1 CREB3L1 CREB3L2 ECHS1 GAN GRB2 HGS HSPH1 MGMT PIAS3 SEMA3F SMAD5 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2K UBE2L3 UBE2R2 UBE2S UBE2T UBE2W UBTD2
Entrez ID		55284	7317
HPRD ID		07724	02440
Ensembl ID		ENSG00000104343	ENSG00000130985
Uniprot IDs		Q96B02 Q96FI0	P22314
PDB IDs		2A7L
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Metabolic Process Cellular Response To Stress Catabolic Process Protein Monoubiquitination Response To Stress Cellular Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Release From Host Cell Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell DNA Repair Negative Regulation Of Viral Transcription Proteolysis Apoptotic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Viral Transcription Programmed Cell Death Negative Regulation Of Viral Process Regulation Of Viral Process Cell Death Death Positive Regulation Of Organelle Organization Genetic Imprinting Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Histone Methylation Histone Ubiquitination Cellular Response To Stimulus	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteolysis Catabolic Process Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Protein Monoubiquitination Cellular Response To Stress Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Response To Organic Substance Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor 3 Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Spindle Assembly Checkpoint
Tagcloud ?		advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Difference) ?		advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured	aspect bax box caspases consisting counterpart debcl degrading documented drosophila e3 fruitfly homologue iaps identifies involve ligase modifier multimeric proteasome proteolytic regulators scf screen shed slimb stimulates trcp ubiquitin
Tagcloud (Intersection) ?