UBE2W and ZNRF1

Number of citations of the paper that reports this interaction (PubMedID 29626159)
33

Data Source:
BioGRID (pull down)

		UBE2W	ZNRF1
Description		ubiquitin conjugating enzyme E2 W	zinc and ring finger 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Synapse
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein Antiviral Innate Immune Response Negative Regulation Of TORC1 Signaling	Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)	Crohn's disease (time to surgery) ( 23665963)
Interacting Genes		81 interacting genes: AKR1C3 AMFR ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM3 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM7 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4	14 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2V1 UBE2V2 UBE2W UBXN7
Entrez ID		55284	84937
HPRD ID		07724	15893
Ensembl ID		ENSG00000104343	ENSG00000186187
Uniprot IDs		Q96B02 Q96FI0 X6REH9	Q8ND25
PDB IDs		2A7L 2MT6 8A58	5YWR
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Transferase Activity Zinc Ion Binding Protein Metabolic Process Metal Ion Binding Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Cytoplasm Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Catabolic Process Innate Immune Response Immune System Process DNA Damage Response Positive Regulation Of Autophagy Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Other Organism Regulation Of Autophagy Regulation Of Signaling Regulation Of Cell Communication Regulation Of Defense Response Defense Response To Symbiont Endoplasmic Reticulum Mannose Trimming Intracellular Signal Transduction Defense Response To Other Organism Response To External Biotic Stimulus	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Proteolysis Nucleotide Binding Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Macromolecule Metabolic Process Transferase Activity Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Catabolic Process ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex ISG15-protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Protein K63-linked Ubiquitination Nucleus Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Protein K6-linked Ubiquitination DNA Metabolic Process DNA Damage Response Postreplication Repair Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination
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