UBE2W and RNF5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		UBE2W	RNF5
Description		ubiquitin conjugating enzyme E2 W	ring finger protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein Antiviral Innate Immune Response Negative Regulation Of TORC1 Signaling	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Protein Destabilization ERAD Pathway Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Soluble receptor for advanced glycation end-product levels ( 26083729) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		81 interacting genes: AKR1C3 AMFR ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM3 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM7 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4	54 interacting genes: ABHD16A ARL6IP1 CFTR CYB561 CYB561A3 DGAT2L6 EPHA2 EPHA3 EPHA4 FAM241B FHOD1 GLP1R INSIG2 JKAMP JMJD6 LEPROTL1 MPDZ MS4A1 ORMDL3 PGAM5 PLP2 PLPP6 PRAF2 PXN RABAC1 RHBDD1 RUSF1 SCD SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM120B TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z UBTD1 YIPF1 YIPF2 YIPF4
Entrez ID		55284	6048
HPRD ID		07724	04057
Ensembl ID		ENSG00000104343	ENSG00000204308
Uniprot IDs		Q96B02 Q96FI0 X6REH9	A0A024RCQ4 Q99942
PDB IDs		2A7L 2MT6 8A58
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Transferase Activity Zinc Ion Binding Protein Metabolic Process Metal Ion Binding Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Cytoplasm Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Catabolic Process Innate Immune Response Immune System Process DNA Damage Response Positive Regulation Of Autophagy Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Other Organism Regulation Of Autophagy Regulation Of Signaling Regulation Of Cell Communication Regulation Of Defense Response Defense Response To Symbiont Endoplasmic Reticulum Mannose Trimming Intracellular Signal Transduction Defense Response To Other Organism Response To External Biotic Stimulus	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination ATP Binding Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Binding Proteolysis Nucleotide Binding Protein K63-linked Ubiquitination Protein Metabolic Process Fasciculation Of Motor Neuron Axon Ephrin Receptor Activity Catabolic Process Membrane Positive Regulation Of Protein Polyubiquitination Fasciculation Of Sensory Neuron Axon UBC13-MMS2 Complex ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Cellular Response To Stress Endoplasmic Reticulum Membrane Regulation Of Protein Polyubiquitination Endosome Proteasomal Protein Catabolic Process ISG15-protein Conjugation Cholesterol Biosynthetic Process GPI-linked Ephrin Receptor Activity Positive Regulation Of Protein K63-linked Ubiquitination Golgi Trans Cisterna Sterol Biosynthetic Process Golgi Medial Cisterna Ubiquitin Protein Ligase Binding Regulation Of Protein Ubiquitination Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Stress Fiber Assembly Protein Catabolic Process Endoplasmic Reticulum Regulation Of Protein K63-linked Ubiquitination
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