SEMA4D

Gene Name		sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
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Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Receptor Binding Protein Binding Semaphorin Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Regulation Of Cell Shape Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho GTPase Activity Negative Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: CD72 PLXNB1 PTPRC
Entrez ID		10507
HPRD ID		03520
Ensembl ID		ENSG00000187764
Uniprot IDs		Q92854
PDB IDs		1OLZ 3OL2
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Negative Regulation Of Cell Adhesion Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Movement Of Cell Or Subcellular Component Bone Development Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Activation Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Protein Autophosphorylation Regulation Of Gamma-delta T Cell Differentiation Skeletal System Development Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Negative T Cell Selection Regulation Of Cell Adhesion Ossification Involved In Bone Maturation Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Humoral Immune Response Bone Maturation Bone Trabecula Morphogenesis
Tagcloud ?		actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection semaphorin shifts strikingly synergistically tme whereby