SEMA4D and PTPRC

Number of citations of the paper that reports this interaction (PMID 11254687)
30

Data Source:
HPRD (in vivo, in vitro)

		SEMA4D	PTPRC
Gene Name		sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	protein tyrosine phosphatase, receptor type, C
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Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Receptor Binding Protein Binding Semaphorin Receptor Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Regulation Of Cell Shape Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho GTPase Activity Negative Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		3 interactors: CD72 PLXNB1 PTPRC	43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70
Entrez ID		10507	5788
HPRD ID		03520	01050
Ensembl ID		ENSG00000187764	ENSG00000081237
Uniprot IDs		Q92854	M9MML4 P08575
PDB IDs		1OLZ 3OL2	1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Negative Regulation Of Cell Adhesion Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Movement Of Cell Or Subcellular Component Bone Development Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Activation Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Protein Autophosphorylation Regulation Of Gamma-delta T Cell Differentiation Skeletal System Development Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Negative T Cell Selection Regulation Of Cell Adhesion Ossification Involved In Bone Maturation Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Humoral Immune Response Bone Maturation Bone Trabecula Morphogenesis	Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection semaphorin shifts strikingly synergistically tme whereby	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Difference) ?		actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection semaphorin shifts strikingly synergistically tme whereby	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Intersection) ?