SEMA4D and PLXNB1

Number of citations of the paper that reports this interaction (PMID 11937491)
28

Data Source:
HPRD (in vivo, in vitro)

		SEMA4D	PLXNB1
Gene Name		sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	plexin B1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Semaphorin Receptor Complex Extracellular Region Intracellular Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Receptor Binding Protein Binding Semaphorin Receptor Binding	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Regulation Of Cell Shape Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho GTPase Activity Negative Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis	Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Positive Regulation Of Rho GTPase Activity Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CD72 PLXNB1 PTPRC	10 interactors: ARHGEF11 ARHGEF12 KMT2A MET PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D
Entrez ID		10507	5364
HPRD ID		03520	03032
Ensembl ID		ENSG00000187764	ENSG00000164050
Uniprot IDs		Q92854	O43157
PDB IDs		1OLZ 3OL2	2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Negative Regulation Of Cell Adhesion Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Movement Of Cell Or Subcellular Component Bone Development Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Activation Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Protein Autophosphorylation Regulation Of Gamma-delta T Cell Differentiation Skeletal System Development Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Negative T Cell Selection Regulation Of Cell Adhesion Ossification Involved In Bone Maturation Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Humoral Immune Response Bone Maturation Bone Trabecula Morphogenesis	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Semaphorin-plexin Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Cell Development Response To External Stimulus Small GTPase Mediated Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Regulation Of Rho Protein Signal Transduction Anatomical Structure Morphogenesis Developmental Process Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Migration Actin Cytoskeleton Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Neurotrophin Signaling Pathway Actin Filament-based Process Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Locomotion Regulation Of Cellular Component Movement Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity Epithelial Cell Morphogenesis
Tagcloud ?		actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection semaphorin shifts strikingly synergistically tme whereby	4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin rejection sema4d semaphorin shifts strikingly synergistically tme whereby
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		4d actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection sema4d semaphorin shifts strikingly synergistically tme whereby