SEMA4D and CD72

Number of citations of the paper that reports this interaction (PMID 11114375)
52

Data Source:
HPRD (in vitro, in vivo)

		SEMA4D	CD72
Gene Name		sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	CD72 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Receptor Binding Protein Binding Semaphorin Receptor Binding	Transmembrane Signaling Receptor Activity Receptor Binding Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Regulation Of Cell Shape Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho GTPase Activity Negative Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis	Cell Adhesion Signal Transduction Axon Guidance
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Axon guidance Semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CD72 PLXNB1 PTPRC	7 interactors: BLNK CD5 GRB2 LYN PTPN6 SEMA4D SYK
Entrez ID		10507	971
HPRD ID		03520	00118
Ensembl ID		ENSG00000187764	ENSG00000137101
Uniprot IDs		Q92854	P21854 Q5TLG3
PDB IDs		1OLZ 3OL2
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Negative Regulation Of Cell Adhesion Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Movement Of Cell Or Subcellular Component Bone Development Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Activation Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Protein Autophosphorylation Regulation Of Gamma-delta T Cell Differentiation Skeletal System Development Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Negative T Cell Selection Regulation Of Cell Adhesion Ossification Involved In Bone Maturation Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Humoral Immune Response Bone Maturation Bone Trabecula Morphogenesis	Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune System Process Regulation Of Cell Activation B Cell Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Platelet Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Antigen Receptor-mediated Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Locomotion Regulation Of Platelet Aggregation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Immune System Process Regulation Of Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Defense Response Regulation Of Body Fluid Levels Wound Healing Chemotaxis Regulation Of MAPK Cascade Hemopoiesis Regulation Of Signal Transduction Positive Regulation Of Immune Response Regulation Of ERK1 And ERK2 Cascade
Tagcloud ?		actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection semaphorin shifts strikingly synergistically tme whereby	ag b bcr blk blocked btk cyclosporin events fk506 gamma2 glycoprotein igm immunosuppressive initiating ligated ligation lyn mature mobilization phospholipase spite stimulated substitute surprisingly syk tec tyrosine unresponsive xid
Tagcloud (Difference) ?		actively architecture broadly cd100 checkpoint colon26 ctla disrupts durable erbb2 immunomodulatory immunotherapies infiltration leukocytes margins microenvironment milieu neutralization orchestrated plexin plxnb1 rejection semaphorin shifts strikingly synergistically tme whereby	ag b bcr blk blocked btk cyclosporin events fk506 gamma2 glycoprotein igm immunosuppressive initiating ligated ligation lyn mature mobilization phospholipase spite stimulated substitute surprisingly syk tec tyrosine unresponsive xid
Tagcloud (Intersection) ?