SEMA4D and CD72

Number of citations of the paper that reports this interaction (PubMedID 12882840)
0

Data Source:
HPRD (in vitro, in vivo)

		SEMA4D	CD72
Description		semaphorin 4D	CD72 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Nucleoplasm Centrosome Plasma Membrane Membrane Ciliary Basal Body Postsynaptic Membrane GABA-ergic Synapse	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Semaphorin Receptor Binding Signaling Receptor Activity Neuropilin Binding Identical Protein Binding Chemorepellent Activity Receptor Ligand Activity	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Nervous System Development Axonogenesis Axon Guidance Regulation Of Cell Shape Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synapse Assembly Bone Trabecula Morphogenesis Regulation Of Biological Quality Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Inhibitory Synapse Assembly	Cell Adhesion Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions	Other semaphorin interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28296344) Brain morphology (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Electroencephalogram traits ( 25387704)
Interacting Genes		6 interacting genes: CD72 CRK DSCAM LINC00839 PLXNB1 PTPRC	22 interacting genes: ATP6AP2 BIK BLNK CD5 CGRRF1 CLDN7 CREB3L1 GPR152 GRAMD1C GRB2 LHFPL5 LMNA LRRC25 LSMEM2 LYN MS4A3 MS4A7 NRG1 PTPN6 SEMA4D SPACA1 SYK
Entrez ID		10507	971
HPRD ID		03520	00118
Ensembl ID		ENSG00000187764	ENSG00000137101
Uniprot IDs		E9PFD9 Q92854	P21854 Q5TLG3
PDB IDs		1OLZ 3OL2
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Adhesion Protein Tyrosine Kinase Binding Signaling Receptor Binding Regulation Of Locomotion Regulation Of Neuron Projection Development Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Development Positive Regulation Of Axonogenesis Negative Regulation Of Cell Adhesion Plasma Membrane Raft Distribution Negative Regulation Of Immune System Process Helper T Cell Diapedesis Regulation Of Catalytic Activity Protein Phosphorylated Amino Acid Binding Regulation Of Leukocyte Mediated Cytotoxicity Response To Cholecystokinin Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Synapse Assembly Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Locomotion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of GTPase Activity Regulation Of Cell Shape Cerebellar Neuron Development Regulation Of Axonogenesis Membrane Microdomain Regulation Of Cell Projection Organization Positive Regulation Of Cell Growth DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Immune Response Transmembrane Signaling Receptor Activity Negative Regulation Of B Cell Receptor Signaling Pathway Cell Adhesion Regulation Of Cell Motility Negative Regulation Of Immune Response Regulation Of Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Anatomical Structure Morphogenesis Diapedesis Positive Regulation Of Growth Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Endothelin Cellular Response To Endothelin Regulation Of Lymphocyte Mediated Immunity	B Cell Receptor Signaling Pathway T Cell Costimulation Membrane Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin SH2 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Plasma Membrane Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Immune Response-activating Signaling Pathway Phosphorylation-dependent Protein Binding Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Activation Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response Regulation Of MAPK Cascade Negative Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Regulation Of Mast Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Phospholipase Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Cellular Component Biogenesis Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion SH3 Domain Binding Negative Regulation Of Defense Response Regulation Of ERK1 And ERK2 Cascade Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Chemorepellent Activity Ephrin Receptor Binding Neutrophil Activation
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