PTPN11 and INPP5D

Number of citations of the paper that reports this interaction (PubMedID 11453982)
0

Data Source:
BioGRID (unspecified method, unspecified method)
HPRD (in vitro, in vivo)

		PTPN11	INPP5D
Description		protein tyrosine phosphatase non-receptor type 11	inositol polyphosphate-5-phosphatase D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Protein-containing Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Membrane Raft
	Molecular Function	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Hydrolase Activity Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Receptor Tyrosine Kinase Binding Cadherin Binding Cell Adhesion Molecule Binding Peptide Hormone Receptor Binding Molecular Adaptor Activity Protein Tyrosine Kinase Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	DNA Damage Checkpoint Signaling Neutrophil Activation Involved In Immune Response Lipid Metabolic Process Triglyceride Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axonogenesis Brain Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Cerebellar Cortex Formation Platelet Formation T Cell Costimulation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Microvillus Organization Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Adhesion Mediated By Integrin Multicellular Organism Growth Organ Growth Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Atrioventricular Canal Development ERBB Signaling Pathway Negative Regulation Of T Cell Proliferation Vasodilation Hormone Metabolic Process Glucose Homeostasis Regulation Of Protein-containing Complex Assembly Regulation Of MAPK Cascade Positive Regulation Of Ossification Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Regulation Of Protein Export From Nucleus Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Genitalia Development Inner Ear Development Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Cortisol Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bergmann Glial Cell Differentiation Negative Regulation Of Growth Hormone Secretion Face Morphogenesis Regulation Of Type I Interferon-mediated Signaling Pathway Intestinal Epithelial Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Activation	Immune System Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Negative Regulation Of Granulocyte Differentiation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Apoptotic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylinositol Dephosphorylation Regulation Of Immune Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation
Pathways		Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Co-inhibition by CTLA4 Co-inhibition by PD-1 Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants SARS-CoV-2 activates/modulates innate and adaptive immune responses Co-inhibition by BTLA	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs		Dodecyltrimethylammonium
Diseases		Metachondromatosis Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood pressure ( 21572416) Body mass index ( 26426971) Diastolic blood pressure ( 26390057) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Glycated hemoglobin levels ( 34059833) HDL cholesterol levels ( 32203549) Hematological parameters ( 19820697) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) Low HDL-cholesterol levels ( 31006500) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Peripheral artery disease ( 31285632) Platelet count ( 32888494 22139419) Reaction time ( 29844566) Response to alcohol consumption (flushing response) ( 29460428) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 30423114 24390342) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Systolic blood pressure ( 26390057 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 17554300) Urate levels ( 23263486) Waist-to-hip ratio adjusted for BMI ( 34054925)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 23128233 22412388) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		167 interacting genes: AATK ACTN4 AKT1 ALK AR ARHGAP1 AXL BCR BDKRB2 BEX1 BEX2 BLZF1 BTLA CALR CAT CAV1 CBL CCKBR CD33 CDC73 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTDSP1 CTLA4 CXCR4 DAB1 DDR1 DMRTC1 EGFR EPHA1 EPHA2 EPOR ERBB2 ERBB3 ERBB4 FCGR1BP FCGR2B FCRL3 FGFR2 FGFR4 FLT1 FLT3 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GARIN5A GHR GMNN GOLGA2 GRB2 GRIN2B GTF2A2 HNRNPU HSP90B1 HSPA5 HSPA9 HSPD1 IFNAR1 IFNGR1 IGF1R IL4R IL6ST ILK INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 LINC01558 LINC02907 LNX1 LRP1 MAP3K4 MAP3K5 MAPK3 MAPT MET MPIG6B MPL MPZL1 MS4A2 MVP NEB NEDD9 NOX4 NSUN5 NSUN5P2 NTRK1 NTRK2 ORMDL3 PAG1 PDGFRA PDGFRB PECAM1 PIK3CA PIK3CG PIK3R1 PILRA PILRB PLCG1 PNCK POU2AF1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTK7 PTPN6 PXN RANGRF RET ROR2 ROS1 RPIA SELE SERF2 SERPINF1 SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SLC38A1 SLN SOCS3 SOS1 SPRY2 SRC SRSF10 STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TLK1 TNFRSF1A TREML1 TRIM32 TRMT2B TSC2 TXNIP	47 interacting genes: ARAP1 CD22 CD300LF CEBPA CRK CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1BP FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID		5781	3635
HPRD ID		01470	09033
Ensembl ID		ENSG00000179295	ENSG00000168918
Uniprot IDs		Q06124	Q92835
PDB IDs		2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4NWF 4NWG 4OHD 4OHE 4OHH 4OHI 4OHL 4PVG 4QSY 4RDD 5BK8 5DF6 5EHP 5EHR 5I6V 5IBM 5IBS 5X7B 5X94 5XZR 6ATD 6BMR 6BMU 6BMV 6BMW 6BMX 6BMY 6BN5 6CMP 6CMQ 6CMR 6CMS 6CRF 6CRG 6MD7 6MD9 6MDA 6MDB 6MDC 6MDD 6R5G 6WU8 7EMN 7JVM 7JVN 7R75 7R7D 7R7I 7R7L 7RCT 7TVJ 7VXG 7XHQ 8B5Y 8CBH 8GWW 8RZW 8RZY 8S01 8S04 8S06 8S07 8S0H 8S0I 8S0J 8S0K 8S0O 8S0P 8S0Q 8S0S 8T6D 8T6G 8T7Q 8T8Q 8U7W 8U7X 8WFY 8WX7 9BLG	2YSX 5RW2 5RW3 5RW4 5RW5 5RW6 5RW7 5RW8 5RW9 5RWA 5RWB 5RWC 5RWD 5RWE 5RWF 5RWG 5RWH 5RWI 5RWJ 5RWK 5RWL 5RWM 5RWN 5RWO 5RWP 5RWQ 5RWR 5RWS 5RWT 5RWU 5RWV 5RWW 5RWX 5RWY 5RWZ 5RX0 5RX1 5RX2 5RX3 5RX4 5RX5 5RX6 5RX7 5RX8 5RX9 5RXA 5RXB 5RXC 5RXD 5RXE 5RXF 5RXG 5RXH 5RXI 5RXJ 5RXK 5RXL 5RXM 5RXO 5RXP 5RXQ 5RXR 5RXS 5RXT 5RXU 5RXV 5RXW 5RXX 5RXY 5RXZ 5RY0 5RY1 5RY2 5RY3 5RY4 5RY5 5RY6 5RY7 5RY8 5RY9 5RYA 5RYB 5RYC 5RYD 5RYE 5RYF 5RYG 5RYH 5RYI 5RYJ 5RYK 5RYL 6IBD 6XY7 8PDG 8PDH 8PDI 8PDJ 8UM5
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Plasma Membrane Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Apoptotic Process Protein Phosphorylation Positive Regulation Of Locomotion Phosphorylation Regulation Of Developmental Process Protein Autophosphorylation Protein Phosphatase Binding Regulation Of Cell Migration Regulation Of Multicellular Organismal Development ATP Binding Regulation Of Cell Motility Regulation Of Immune System Process Regulation Of Cell Adhesion Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Developmental Process Immune System Process Cell Migration Positive Regulation Of Developmental Process	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of MAPK Cascade Negative Regulation Of Immune Response Regulation Of Immune Response Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Cell Migration Positive Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Phosphatase Binding Cell Motility Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Vesicle-mediated Transport Cellular Developmental Process Positive Regulation Of Cell Migration Fc-gamma Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction Positive Regulation Of Locomotion Leukocyte Differentiation Cell Differentiation Negative Regulation Of Leukocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Effector Process Regulation Of Cell Shape Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Lymphocyte Activation Plasma Membrane Negative Regulation Of Cell Activation Regulation Of Cell Population Proliferation
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