PTPN11 and DAB1

Number of citations of the paper that reports this interaction (PMID 15062102)
43

Data Source:
HPRD (in vitro)

		PTPN11	DAB1
Gene Name		protein tyrosine phosphatase, non-receptor type 11	Dab, reelin signal transducer, homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Protein Complex	Cytosol Brush Border Postsynaptic Density Membrane Neuron Projection Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding D1 Dopamine Receptor Binding Phospholipase Binding Insulin Receptor Substrate Binding Peptide Hormone Receptor Binding	Phosphatidylinositol 3-kinase Binding
	Biological Process	DNA Damage Checkpoint Activation Of MAPK Activity Triglyceride Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Brain Development Heart Development Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Adhesion Mediated By Integrin Organ Growth Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Atrioventricular Canal Development Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Multicellular Organism Growth Hormone Metabolic Process Glucose Homeostasis Innate Immune Response Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion Regulation Of Protein Export From Nucleus Positive Regulation Of Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Multicellular Organismal Reproductive Process Genitalia Development Inner Ear Development Leukocyte Migration Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Face Morphogenesis Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Midgut Development Adult Walking Behavior Dendrite Development Ventral Spinal Cord Development Cerebellum Structural Organization Cerebral Cortex Radially Oriented Cell Migration Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Golgi Localization Lateral Motor Column Neuron Migration
Pathways		Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling
Drugs		Dodecane-Trimethylamine
Diseases
GWAS		Blood pressure ( 21572416) Hematological parameters ( 19820697) Hypothyroidism ( 22493691) Platelet counts ( 22139419) Retinal vascular caliber ( 21060863) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 17554300) Urate levels ( 23263486)	Bulimia nervosa ( 23568457) Immune reponse to smallpox (secreted IL-10) ( 22610502) Kawasaki disease ( 21221998) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		114 interactors: ACTN4 ARHGAP1 AXL BCR BDKRB2 BTLA C6orf25 CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTLA4 CXCR4 DAB1 DDR1 EGFR EPHA2 EPOR ERBB2 FCRL3 FLT1 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GRB2 GRIN2B HNRNPU IFNAR1 IFNGR1 IGF1R IL4R IL6ST INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 MAP3K4 MAP3K5 MAPK3 MET MPL MPZL1 MS4A2 MVP NEDD9 NTRK1 NTRK2 PAG1 PDGFRA PDGFRB PECAM1 PIK3CG PIK3R1 PILRA PILRB PLCG1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTPN6 PXN RET ROS1 RPIA SELE SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SOCS3 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TNFRSF1A TREML1 TRIM32	73 interactors: APLP1 APLP2 APP ARID5A BHLHE40 C1orf94 CDK5 CDK6 CIART CLASRP CRK CRKL DAB2IP DAZAP2 ERBB2 ERBB3 FAM103A1 FAM168A HMBOX1 HNRNPLL HYAL3 INPP5D ITGB2 ITGB3 ITGB5 ITGB7 KRTAP19-5 KRTAP19-7 KRTAP8-1 LDLR LGALS9B LGALS9C LNX1 LRP1 LRP2 LRP8 MAGED1 MBNL1 MBNL3 MYO6 NAF1 PAFAH1B1 PCDH18 PIN1 PLCG1 POGZ PPIG PRR20A PTPN11 RBFOX1 RBFOX2 RELN RHOXF2 ROR2 SERF2 SIAH1 SIRPB1 SMAP2 SNRPB SRC STRBP TCEA2 TCEANC TMTC3 TOLLIP USP53 VENTX VLDLR WDYHV1 ZBTB32 ZC3H10 ZCCHC10 ZNF488
Entrez ID		5781	1600
HPRD ID		01470	04582
Ensembl ID		ENSG00000179295	ENSG00000173406
Uniprot IDs		Q06124	O75553
PDB IDs		2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 4DGP 4DGX 4GWF 4H1O 4H34 4JE4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Response To Organic Substance Immune System Process Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Organic Substance Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation ERBB Signaling Pathway Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Response To Growth Factor Regulation Of Immune Response Positive Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Growth Hormone Receptor Signaling Pathway Defense Response Regulation Of Protein Phosphorylation Protein Autophosphorylation Cellular Response To Growth Hormone Stimulus Cell Migration Regulation Of Body Fluid Levels Positive Regulation Of MAPK Cascade Response To Cytokine Response To Stress Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Cell Motility Positive Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Protein Modification Process Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Reelin-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Developmental Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Central Nervous System Development Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Nervous System Development Brain Development Regulation Of Cellular Protein Metabolic Process Gliogenesis Regulation Of Protein Metabolic Process Head Development Anatomical Structure Morphogenesis Response To External Stimulus Cell Surface Receptor Signaling Pathway Forebrain Development System Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Cellular Metabolic Process Organ Development Wound Healing Immune System Process Layer Formation In Cerebral Cortex Locomotion Neuron Projection Morphogenesis Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signaling Endocytosis MRNA Processing Neurogenesis Cerebral Cortex Radial Glia Guided Migration
Tagcloud ?		absolute case cases count died eleven female indispensable interval jmml juvenile male median monocytes mutation myelomonocytic observation obviously onset peripheral platelet plt progressive ras retrospectively slow sure wbc white	assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical
Tagcloud (Difference) ?		absolute case cases count died eleven female indispensable interval jmml juvenile male median monocytes mutation myelomonocytic observation obviously onset peripheral platelet plt progressive ras retrospectively slow sure wbc white	assist cajal connections cortical d1x dieker disabled doublecortn dubbed dysplasias hydrolase instructs lis1 lissencephaly malformation marginal miller neuregulin neurotrophic neurotrophin p35 plate preplate radial reelin retzius tangential tbr thalamocortical
Tagcloud (Intersection) ?