PTPN11 and JAK2

  • Number of citations of the paper that reports this interaction (PMID 8995399)
  • 15
  • Data Source:
  • HPRD (in vivo)

PTPN11

JAK2

Gene Name protein tyrosine phosphatase, non-receptor type 11 Janus kinase 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 114 interactors: ACTN4 ARHGAP1 AXL BCR BDKRB2 BTLA C6orf25 CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTLA4 CXCR4 DAB1 DDR1 EGFR EPHA2 EPOR ERBB2 FCRL3 FLT1 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GRB2 GRIN2B HNRNPU IFNAR1 IFNGR1 IGF1R IL4R IL6ST INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 MAP3K4 MAP3K5 MAPK3 MET MPL MPZL1 MS4A2 MVP NEDD9 NTRK1 NTRK2 PAG1 PDGFRA PDGFRB PECAM1 PIK3CG PIK3R1 PILRA PILRB PLCG1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTPN6 PXN RET ROS1 RPIA SELE SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SOCS3 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TNFRSF1A TREML1 TRIM32 94 interactors: ABL1 AGTR1 ASS1 BCR BRCA1 CCR5 CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I HES1 HES5 HIST3H3 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1
Entrez ID 5781 3717
HPRD ID 01470 00993
Ensembl ID ENSG00000179295 ENSG00000096968
Uniprot IDs Q06124 O60674
PDB IDs 2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
absolute  case  cases  count  died  eleven  female  indispensable  interval  jmml  juvenile  male  median  monocytes  mutation  myelomonocytic  observation  obviously  onset  peripheral  platelet  plt  progressive  ras  retrospectively  slow  sure  wbc  white 
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
Tagcloud (Difference) ?
absolute  case  cases  count  died  eleven  female  indispensable  interval  jmml  juvenile  male  median  monocytes  mutation  myelomonocytic  observation  obviously  onset  peripheral  platelet  plt  progressive  ras  retrospectively  slow  sure  wbc  white 
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
Tagcloud (Intersection) ?