PTPN11 and CSF2RB

Number of citations of the paper that reports this interaction (PMID 9162089)
8

Data Source:
HPRD (in vitro, in vivo)

		PTPN11	CSF2RB
Gene Name		protein tyrosine phosphatase, non-receptor type 11	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Protein Complex	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding D1 Dopamine Receptor Binding Phospholipase Binding Insulin Receptor Substrate Binding Peptide Hormone Receptor Binding	Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding
	Biological Process	DNA Damage Checkpoint Activation Of MAPK Activity Triglyceride Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Brain Development Heart Development Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Adhesion Mediated By Integrin Organ Growth Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Atrioventricular Canal Development Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Multicellular Organism Growth Hormone Metabolic Process Glucose Homeostasis Innate Immune Response Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion Regulation Of Protein Export From Nucleus Positive Regulation Of Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Multicellular Organismal Reproductive Process Genitalia Development Inner Ear Development Leukocyte Migration Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Face Morphogenesis Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glucose Import In Response To Insulin Stimulus	Signal Transduction Respiratory Gaseous Exchange Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway
Pathways		Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Dodecane-Trimethylamine
Diseases
GWAS		Blood pressure ( 21572416) Hematological parameters ( 19820697) Hypothyroidism ( 22493691) Platelet counts ( 22139419) Retinal vascular caliber ( 21060863) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 17554300) Urate levels ( 23263486)
Protein-Protein Interactions		114 interactors: ACTN4 ARHGAP1 AXL BCR BDKRB2 BTLA C6orf25 CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTLA4 CXCR4 DAB1 DDR1 EGFR EPHA2 EPOR ERBB2 FCRL3 FLT1 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GRB2 GRIN2B HNRNPU IFNAR1 IFNGR1 IGF1R IL4R IL6ST INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 MAP3K4 MAP3K5 MAPK3 MET MPL MPZL1 MS4A2 MVP NEDD9 NTRK1 NTRK2 PAG1 PDGFRA PDGFRB PECAM1 PIK3CG PIK3R1 PILRA PILRB PLCG1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTPN6 PXN RET ROS1 RPIA SELE SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SOCS3 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TNFRSF1A TREML1 TRIM32	27 interactors: CISH CSF2 CSF2RA EPOR FES FYN GNB2L1 HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		5781	1439
HPRD ID		01470	00739
Ensembl ID		ENSG00000179295	ENSG00000100368
Uniprot IDs		Q06124	B4DZL8 P32927 Q6NSJ8
PDB IDs		2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 4DGP 4DGX 4GWF 4H1O 4H34 4JE4	1C8P 1EGJ 1GH7 2GYS 3CXE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Response To Organic Substance Immune System Process Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Organic Substance Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation ERBB Signaling Pathway Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Response To Growth Factor Regulation Of Immune Response Positive Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Growth Hormone Receptor Signaling Pathway Defense Response Regulation Of Protein Phosphorylation Protein Autophosphorylation Cellular Response To Growth Hormone Stimulus Cell Migration Regulation Of Body Fluid Levels Positive Regulation Of MAPK Cascade Response To Cytokine Response To Stress Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Cell Motility Positive Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Protein Modification Process Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Organic Substance Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Immune Response Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Response To Cytokine Immune System Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Defense Response Regulation Of Immune Response Cellular Response To Peptide Hormone Stimulus Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Innate Immune Response Regulation Of Immune System Process Regulation Of JAK-STAT Cascade Regulation Of Signal Transduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Signal Transduction Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Intracellular Signal Transduction Regulation Of Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cell Migration Signaling Response To Peptide Cell Communication Leukocyte Migration Cellular Response To Stimulus Cell Motility Response To Growth Hormone Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Amino Acid Metabolic Process Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Tagcloud ?		absolute case cases count died eleven female indispensable interval jmml juvenile male median monocytes mutation myelomonocytic observation obviously onset peripheral platelet plt progressive ras retrospectively slow sure wbc white	11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133
Tagcloud (Difference) ?		absolute case cases count died eleven female indispensable interval jmml juvenile male median monocytes mutation myelomonocytic observation obviously onset peripheral platelet plt progressive ras retrospectively slow sure wbc white	11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133
Tagcloud (Intersection) ?