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PTPN11 and PILRA
Number of citations of the paper that reports this interaction (PMID
10660620
)
20
Data Source:
HPRD
(in vivo)
PTPN11
PILRA
Gene Name
protein tyrosine phosphatase, non-receptor type 11
paired immunoglobin-like type 2 receptor alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Protein Complex
Plasma Membrane
Integral Component Of Membrane
Extracellular Vesicular Exosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
SH3/SH2 Adaptor Activity
Insulin Receptor Binding
Protein Binding
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
D1 Dopamine Receptor Binding
Phospholipase Binding
Insulin Receptor Substrate Binding
Peptide Hormone Receptor Binding
Protein Binding
Biological Process
DNA Damage Checkpoint
Activation Of MAPK Activity
Triglyceride Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Brain Development
Heart Development
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Platelet Formation
T Cell Costimulation
Abortive Mitotic Cell Cycle
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Cell Adhesion Mediated By Integrin
Organ Growth
Peptidyl-tyrosine Dephosphorylation
Megakaryocyte Development
Atrioventricular Canal Development
Fc-epsilon Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Glucose Homeostasis
Innate Immune Response
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Insulin Secretion
Regulation Of Protein Export From Nucleus
Positive Regulation Of Hormone Secretion
Platelet-derived Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Multicellular Organismal Reproductive Process
Genitalia Development
Inner Ear Development
Leukocyte Migration
Negative Regulation Of Cortisol Secretion
Negative Regulation Of Growth Hormone Secretion
Face Morphogenesis
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Signal Transduction
Viral Process
Pathways
Signaling by FGFR in disease
Netrin mediated repulsion signals
Signaling by EGFRvIII in Cancer
Interferon gamma signaling
Downstream signaling events of B Cell Receptor (BCR)
Toll Like Receptor TLR1:TLR2 Cascade
PI3K/AKT activation
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
SOS-mediated signalling
Prolactin receptor signaling
SHC-mediated signalling
PI3K Cascade
TRIF-mediated TLR3/TLR4 signaling
ERK1 activation
ERK1 activation
Spry regulation of FGF signaling
Constitutive PI3K/AKT Signaling in Cancer
Platelet sensitization by LDL
Signaling by VEGF
Signalling to RAS
Toll Like Receptor 3 (TLR3) Cascade
Downstream signal transduction
Interleukin-2 signaling
PI3K/AKT Signaling in Cancer
Frs2-mediated activation
Adaptive Immune System
Axon guidance
IRS-mediated signalling
Interleukin-6 signaling
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
GRB2 events in ERBB2 signaling
VEGFR2 mediated cell proliferation
PI3K events in ERBB2 signaling
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
NCAM signaling for neurite out-growth
Netrin-1 signaling
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Innate Immune System
Signaling by Insulin receptor
Insulin receptor signalling cascade
Interferon Signaling
CTLA4 inhibitory signaling
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
SHC-related events
Tie2 Signaling
PECAM1 interactions
Signaling by FGFR
ARMS-mediated activation
Nuclear signaling by ERBB4
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PD-1 signaling
PI3K Cascade
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
FCERI mediated MAPK activation
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
DAP12 signaling
PI-3K cascade
Toll Like Receptor 9 (TLR9) Cascade
Negative regulation of FGFR signaling
Signaling by PDGF
DAP12 interactions
Regulation of IFNA signaling
GAB1 signalosome
GRB2 events in EGFR signaling
SHC-related events triggered by IGF1R
Signal regulatory protein (SIRP) family interactions
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Toll Like Receptor 2 (TLR2) Cascade
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Platelet homeostasis
Toll Like Receptor 4 (TLR4) Cascade
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
Interleukin-3, 5 and GM-CSF signaling
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
Costimulation by the CD28 family
ERK activation
PIP3 activates AKT signaling
Toll Like Receptor 7/8 (TLR7/8) Cascade
IGF1R signaling cascade
Toll Like Receptor TLR6:TLR2 Cascade
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IRS-related events triggered by IGF1R
MyD88 cascade initiated on plasma membrane
ERK activation
Downstream signaling of activated FGFR
Interferon alpha/beta signaling
Signalling by NGF
SOS-mediated signalling
MAP kinase activation in TLR cascade
SHC-mediated signalling
Cytokine Signaling in Immune system
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
MyD88-independent cascade
Cell surface interactions at the vascular wall
ERK2 activation
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
ERK2 activation
Regulation of IFNG signaling
Drugs
Dodecane-Trimethylamine
Diseases
GWAS
Blood pressure (
21572416
)
Hematological parameters (
19820697
)
Hypothyroidism (
22493691
)
Platelet counts (
22139419
)
Retinal vascular caliber (
21060863
)
Tetralogy of Fallot (
23297363
)
Type 1 diabetes (
17554300
)
Urate levels (
23263486
)
Protein-Protein Interactions
114 interactors:
ACTN4
ARHGAP1
AXL
BCR
BDKRB2
BTLA
C6orf25
CAT
CAV1
CBL
CCKBR
CD33
CDH5
CEACAM1
CHUK
CRKL
CSF2RB
CSF3R
CTLA4
CXCR4
DAB1
DDR1
EGFR
EPHA2
EPOR
ERBB2
FCRL3
FLT1
FLT4
FRS2
FRS3
FYN
GAB1
GAB2
GAB3
GHR
GRB2
GRIN2B
HNRNPU
IFNAR1
IFNGR1
IGF1R
IL4R
IL6ST
INPP5D
INSR
IRS1
IRS2
IRS4
JAK1
JAK2
KDR
KIR2DL5A
KIT
KLRC1
LAIR1
LCK
LEPR
LIFR
LILRB4
MAP3K4
MAP3K5
MAPK3
MET
MPL
MPZL1
MS4A2
MVP
NEDD9
NTRK1
NTRK2
PAG1
PDGFRA
PDGFRB
PECAM1
PIK3CG
PIK3R1
PILRA
PILRB
PLCG1
PRKCA
PRKCB
PRKCH
PRLR
PTK2
PTK2B
PTPN6
PXN
RET
ROS1
RPIA
SELE
SHC1
SIGLEC11
SIGLEC12
SIGLEC7
SIRPA
SIT1
SLAMF1
SLAMF6
SOCS3
SOS1
SPRY2
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNCRIP
TEK
TIE1
TNFRSF1A
TREML1
TRIM32
5 interactors:
DNPH1
FCAR
PTPN11
PTPN6
SORBS1
Entrez ID
5781
29992
HPRD ID
01470
05631
Ensembl ID
ENSG00000179295
ENSG00000085514
Uniprot IDs
Q06124
C9JJ79
Q9UKJ1
PDB IDs
2SHP
3B7O
3MOW
3O5X
3TKZ
3TL0
4DGP
4DGX
4GWF
4H1O
4H34
4JE4
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Signal Transduction
Cell Surface Receptor Signaling Pathway
Signaling
Cell Communication
Cellular Response To Stimulus
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Signal Transduction
Response To Organic Substance
Immune System Process
Positive Regulation Of Intracellular Signal Transduction
Response To Stimulus
Cellular Response To Organic Substance
Regulation Of Signal Transduction
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorylation
ERBB Signaling Pathway
Regulation Of Immune System Process
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Phosphorylation
Response To Growth Factor
Regulation Of Immune Response
Positive Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Cellular Response To Growth Factor Stimulus
Growth Hormone Receptor Signaling Pathway
Defense Response
Regulation Of Protein Phosphorylation
Protein Autophosphorylation
Cellular Response To Growth Hormone Stimulus
Cell Migration
Regulation Of Body Fluid Levels
Positive Regulation Of MAPK Cascade
Response To Cytokine
Response To Stress
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cell Proliferation
Cell Motility
Positive Regulation Of Kinase Activity
Innate Immune Response
Positive Regulation Of Protein Modification Process
Protein Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Abortive Mitotic Cell Cycle
Megakaryocyte Development
Platelet Formation
Platelet Morphogenesis
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Response To Interferon-gamma
Megakaryocyte Differentiation
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Glucose Import
Positive Regulation Of Glucose Transport
Response To Peptide Hormone
Regulation Of Glucose Import
Cellular Response To Organonitrogen Compound
Response To Peptide
T Cell Costimulation
Cellular Response To Hormone Stimulus
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Glucose Transport
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Negative Regulation Of Cortisol Secretion
Negative Regulation Of Growth Hormone Secretion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Type I Interferon
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Insulin Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Response To Organonitrogen Compound
Deoxyribonucleoside Monophosphate Catabolic Process
Response To Interferon-gamma
Enzyme Linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Glucocorticoid Secretion
Response To Hormone
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Cellular Localization
Cellular Response To Insulin Stimulus
Positive Regulation Of Homotypic Cell-cell Adhesion
Leukocyte Migration
Bone Development
Negative Regulation Of B Cell Receptor Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Regulation Of Innate Immune Response
Myeloid Cell Differentiation
Tagcloud
?
absolute
case
cases
count
died
eleven
female
indispensable
interval
jmml
juvenile
male
median
monocytes
mutation
myelomonocytic
observation
obviously
onset
peripheral
platelet
plt
progressive
ras
retrospectively
slow
sure
wbc
white
Tagcloud (Difference)
?
absolute
case
cases
count
died
eleven
female
indispensable
interval
jmml
juvenile
male
median
monocytes
mutation
myelomonocytic
observation
obviously
onset
peripheral
platelet
plt
progressive
ras
retrospectively
slow
sure
wbc
white
Tagcloud (Intersection)
?