FANCM and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		FANCM	ECT2
Description		FA complementation group M	epithelial cell transforming 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Helicase Activity Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Replication Fork Processing Homologous Recombination Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Protein Monoubiquitination	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases		Fanconi anemia
GWAS		Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		57697	1894
HPRD ID		13876	11860
Ensembl ID		ENSG00000187790	ENSG00000114346
Uniprot IDs		A0A8Q3WLG3 Q8IYD8	Q9H8V3
PDB IDs		4BXO 4DAY 4DRB 4E45 4M6W	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		Resolution Of DNA Recombination Intermediates Resolution Of Meiotic Recombination Intermediates RecQ Family Helicase-topoisomerase III Complex FANCM-MHF Complex Response To Stress Cellular Response To Manganese Ion Cellular Response To Stress DNA Repair Meiosis I Cell Cycle Process Fanconi Anaemia Nuclear Complex Response To Manganese Ion Golgi-associated Vesicle Reproductive Process Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity DNA Metabolic Process DNA Damage Response Presynaptic Cytosol Cellular Response To Metal Ion Regulation Of Neuron Differentiation Clathrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interstrand Cross-link Repair Replication Fork Processing Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Macromolecule Metabolic Process Double-strand Break Repair Regulation Of CAMP/PKA Signal Transduction DNA Recombination Modulation Of Excitatory Postsynaptic Potential Protein Sumoylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleoplasm Cytosol DNA Binding Endosome Acetylcholine Receptor Activator Activity Response To Metal Ion Positive Regulation Of Protein Metabolic Process	Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination
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