FANCM and EPN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FANCM	EPN2
Description		FA complementation group M	epsin 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Cytoplasm Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Helicase Activity Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Cadherin Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Replication Fork Processing Homologous Recombination Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Protein Monoubiquitination	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Fanconi anemia
GWAS		Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I	42 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 RPS27A SMAD1 SNCA SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		57697	22905
HPRD ID		13876	06271
Ensembl ID		ENSG00000187790	ENSG00000072134
Uniprot IDs		A0A8Q3WLG3 Q8IYD8	O95208
PDB IDs		4BXO 4DAY 4DRB 4E45 4M6W
Enriched GO Terms of Interacting Partners?		Resolution Of DNA Recombination Intermediates Resolution Of Meiotic Recombination Intermediates RecQ Family Helicase-topoisomerase III Complex FANCM-MHF Complex Response To Stress Cellular Response To Manganese Ion Cellular Response To Stress DNA Repair Meiosis I Cell Cycle Process Fanconi Anaemia Nuclear Complex Response To Manganese Ion Golgi-associated Vesicle Reproductive Process Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity DNA Metabolic Process DNA Damage Response Presynaptic Cytosol Cellular Response To Metal Ion Regulation Of Neuron Differentiation Clathrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interstrand Cross-link Repair Replication Fork Processing Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Macromolecule Metabolic Process Double-strand Break Repair Regulation Of CAMP/PKA Signal Transduction DNA Recombination Modulation Of Excitatory Postsynaptic Potential Protein Sumoylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleoplasm Cytosol DNA Binding Endosome Acetylcholine Receptor Activator Activity Response To Metal Ion Positive Regulation Of Protein Metabolic Process	Ubiquitin Protein Ligase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification WW Domain Binding Endosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Sequestering Activity Protein Tag Activity Cytoplasmic Side Of Late Endosome Membrane Identical Protein Binding Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Lysosome Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Protein K6-linked Ubiquitination Protein Binding Intracellular Protein Localization Positive Regulation Of Cell Communication Receptor-mediated Endocytosis Cytoplasm Regulation Of Signaling Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Negative Regulation Of Signal Transduction Phosphoprotein Binding Clathrin Coat Of Coated Pit Mitochondrial Outer Membrane Positive Regulation Of Protein Ubiquitination Macromolecule Catabolic Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Establishment Of Protein Localization Positive Regulation Of Receptor Catabolic Process Regulation Of Cell Communication Postsynaptic Endocytic Zone Negative Regulation Of Translational Initiation Proteolysis Involved In Protein Catabolic Process Cytoplasmic Translation Lysosomal Membrane Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Protein Localization To Lysosome Positive Regulation Of Receptor Recycling Cytoplasmic Side Of Lysosomal Membrane Catabolic Process
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