FANCM

Name	FA complementation group M
Structure
Interactors	11 interactors: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Helicase Activity Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Replication Fork Processing Homologous Recombination Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Protein Monoubiquitination
Pathways	Fanconi Anemia Pathway PKR-mediated signaling
Diseases	Fanconi anemia
GWAS	Metabolite levels ( 23823483 ) Nicotine dependence symptom count ( 25555482 ) Severe influenza A (H1N1) infection ( 26379185 )
Entrez ID	57697
HPRD ID	13876
Ensembl ID	ENSG00000187790
Uniprot IDs	A0A8Q3WLG3 Q8IYD8
PDB IDs	4BXO 4DAY 4DRB 4E45 4M6W
GO Terms Enriched among Interactors ?	Resolution Of DNA Recombination Intermediates Resolution Of Meiotic Recombination Intermediates RecQ Family Helicase-topoisomerase III Complex FANCM-MHF Complex Response To Stress Cellular Response To Manganese Ion Cellular Response To Stress DNA Repair Meiosis I Cell Cycle Process Fanconi Anaemia Nuclear Complex Response To Manganese Ion Golgi-associated Vesicle Reproductive Process Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity DNA Metabolic Process DNA Damage Response Presynaptic Cytosol Cellular Response To Metal Ion Regulation Of Neuron Differentiation Clathrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interstrand Cross-link Repair Replication Fork Processing Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Macromolecule Metabolic Process Double-strand Break Repair Regulation Of CAMP/PKA Signal Transduction DNA Recombination Modulation Of Excitatory Postsynaptic Potential Protein Sumoylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleoplasm Cytosol DNA Binding Endosome Acetylcholine Receptor Activator Activity Response To Metal Ion Positive Regulation Of Protein Metabolic Process