CHD8 and TOP3B

Number of citations of the paper that reports this interaction (PMID 11549288)
1

Data Source:
HPRD (two hybrid)

		CHD8	TOP3B
Gene Name		chromodomain helicase DNA binding protein 8	topoisomerase (DNA) III beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Protein Complex MLL1 Complex	Condensed Chromosome Nucleus Nucleoplasm
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding	DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Brain Development Negative Regulation Of Wnt Signaling Pathway DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Digestive Tract Development Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	DNA Topological Change Chromosome Segregation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AR ASH2L CREB1 CTCF CTNNB1 RBBP5 RCHY1 TOP3B WDR5	18 interactors: ADAMTSL4 C1QBP CENPF CHD8 CHIC2 FBLN5 GRN KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF408
Entrez ID		57680	8940
HPRD ID		16712	04662
Ensembl ID		ENSG00000100888	ENSG00000100038
Uniprot IDs		Q9HCK8	A8K4N2 O95985
PDB IDs		2CKA 2DL6
Enriched GO Terms of Interacting Partners?		Histone H3-K4 Methylation Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Lysine Methylation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Sister Chromatid Cohesion Response To Hormone Methylation Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Methylation Positive Regulation Of Metabolic Process Gene Expression Chromatin Modification Cellular Macromolecule Biosynthetic Process Response To Estrogen Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Chromatin Organization Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Lung Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Osteoclast Differentiation Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Histone Modification Biosynthetic Process	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interleukin-4 Biosynthetic Process Negative Regulation Of Mast Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of MDA-5 Signaling Pathway Mitral Valve Formation Cellular Macromolecule Biosynthetic Process Regulation Of Interferon-gamma Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Transcriptional Activation By Promoter-enhancer Looping Tricuspid Valve Formation Tricuspid Valve Morphogenesis Primitive Erythrocyte Differentiation Tricuspid Valve Development Blood Coagulation Hemostasis Regulation Of Definitive Erythrocyte Differentiation Regulation Of Mast Cell Differentiation Intraciliary Transport Involved In Cilium Morphogenesis Positive Regulation Of Mitochondrial Translation Mitral Valve Morphogenesis Definitive Erythrocyte Differentiation Organelle Assembly Cellular Localization Negative Regulation Of Interleukin-4 Production Positive Regulation Of Dendritic Cell Chemotaxis Mitral Valve Development Elastic Fiber Assembly Chromosome Organization Protein Localization To Microtubule
Tagcloud ?		advance autism binds breakthrough candidate catenin central chromodomain de developmental discovery disorder disorders exon frequently gene helicase latest mutated nervous novo provides regulate sequencing spectrum still suggesting targets whole	accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn
Tagcloud (Difference) ?		advance autism binds breakthrough candidate catenin central chromodomain de developmental discovery disorder disorders exon frequently gene helicase latest mutated nervous novo provides regulate sequencing spectrum still suggesting targets whole	accelerate advancing aging bubr1 claimed ebp ghr ghrhr gompertz insr instance interpreted klotho lmna longevity msra pit1 polga prdx1 prop1 prove retard shc1 span straightforward tables terc trx wrn
Tagcloud (Intersection) ?