CHD8

Gene Name		chromodomain helicase DNA binding protein 8
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Protein Complex MLL1 Complex
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Brain Development Negative Regulation Of Wnt Signaling Pathway DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Digestive Tract Development Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: AR ASH2L CREB1 CTCF CTNNB1 RBBP5 RCHY1 TOP3B WDR5
Entrez ID		57680
HPRD ID		16712
Ensembl ID		ENSG00000100888
Uniprot IDs		Q9HCK8
PDB IDs		2CKA 2DL6
Enriched GO Terms of Interacting Partners?		Histone H3-K4 Methylation Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Lysine Methylation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Sister Chromatid Cohesion Response To Hormone Methylation Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Methylation Positive Regulation Of Metabolic Process Gene Expression Chromatin Modification Cellular Macromolecule Biosynthetic Process Response To Estrogen Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Chromatin Organization Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Lung Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Osteoclast Differentiation Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Histone Modification Biosynthetic Process
Tagcloud ?		advance autism binds breakthrough candidate catenin central chromodomain de developmental discovery disorder disorders exon frequently gene helicase latest mutated nervous novo provides regulate sequencing spectrum still suggesting targets whole