CHD8 and CTCF

Number of citations of the paper that reports this interaction (PMID 16949368)
72

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CHD8	CTCF
Gene Name		chromodomain helicase DNA binding protein 8	CCCTC-binding factor (zinc finger protein)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Protein Complex MLL1 Complex	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Brain Development Negative Regulation Of Wnt Signaling Pathway DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Digestive Tract Development Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Chromosome Segregation Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Chromatin Modification Nucleosome Positioning Regulation Of Histone Methylation Regulation Of Histone Acetylation Regulation Of Gene Expression, Epigenetic Regulation Of Molecular Function, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Centromeric Sister Chromatid Cohesion
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS			HDL cholesterol ( 19060911)
Protein-Protein Interactions		9 interactors: AR ASH2L CREB1 CTCF CTNNB1 RBBP5 RCHY1 TOP3B WDR5	13 interactors: CHD7 CHD8 HMGB1 POLR2A RXRA SIN3A SMAD3 SMAD4 SUZ12 THRB TRB YBX1 ZMYM4
Entrez ID		57680	10664
HPRD ID		16712	05005
Ensembl ID		ENSG00000100888	ENSG00000102974
Uniprot IDs		Q9HCK8	P49711
PDB IDs		2CKA 2DL6	1X6H 2CT1
Enriched GO Terms of Interacting Partners?		Histone H3-K4 Methylation Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Lysine Methylation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Sister Chromatid Cohesion Response To Hormone Methylation Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Methylation Positive Regulation Of Metabolic Process Gene Expression Chromatin Modification Cellular Macromolecule Biosynthetic Process Response To Estrogen Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Chromatin Organization Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Response To Lipid Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Lung Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Osteoclast Differentiation Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Histone Modification Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process In Utero Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Embryo Development Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Developmental Process Nitrogen Compound Metabolic Process Heart Morphogenesis Positive Regulation Of Metabolic Process Multicellular Organismal Development Biosynthetic Process SMAD Protein Complex Assembly Regulation Of Binding Anatomical Structure Development Chromatin Modification Regulation Of Transforming Growth Factor Beta2 Production Tube Development Chromatin Organization
Tagcloud ?		advance autism binds breakthrough candidate catenin central chromodomain de developmental discovery disorder disorders exon frequently gene helicase latest mutated nervous novo provides regulate sequencing spectrum still suggesting targets whole	acting angle bend bending binds chicken confer direction efficiently erba f1 f2 fails flexure hetero heterodimer homodimer homologue lysozyme magnitude nep1 quaternary represses rxr silencer simultaneously synergistically t3 tr
Tagcloud (Difference) ?		advance autism breakthrough candidate catenin central chromodomain de developmental discovery disorder disorders exon frequently gene helicase latest mutated nervous novo provides regulate sequencing spectrum still suggesting targets whole	acting angle bend bending chicken confer direction efficiently erba f1 f2 fails flexure hetero heterodimer homodimer homologue lysozyme magnitude nep1 quaternary represses rxr silencer simultaneously synergistically t3 tr
Tagcloud (Intersection) ?		binds