PLEKHA4 and EEF1G

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLEKHA4	EEF1G
Gene Name		pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	eukaryotic translation elongation factor 1 gamma
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm Membrane	Nucleus Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	1-phosphatidylinositol Binding	Translation Elongation Factor Activity Protein Binding
	Biological Process	Biological_process	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process
Pathways			Translation Eukaryotic Translation Elongation
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CCNG1 EEF1G KAT5 LRIF1 PRKAA1 SETDB1	87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24
Entrez ID		57664	1937
HPRD ID		09683	11745
Ensembl ID		ENSG00000105559	ENSG00000254772
Uniprot IDs		Q9H4M7	P26641 Q53YD7
PDB IDs		1UPQ 1UPR	1PBU
Enriched GO Terms of Interacting Partners?		Histone Modification Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Chromatin Modification Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Organization Response To Ionizing Radiation Negative Regulation Of Glucose Import In Response To Insulin Stimulus Response To Camptothecin Transcription, DNA-templated Peptidyl-amino Acid Modification RNA Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chromosome Organization Peptidyl-lysine Modification Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Histone H3-K9 Trimethylation Cellular Response To Ethanol Negative Regulation Of Glucose Import Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Fatty Acid Homeostasis Organelle Organization RNA Metabolic Process Negative Regulation Of Glucose Transport Mitotic G2 DNA Damage Checkpoint Cellular Response To Stress Cellular Response To Estradiol Stimulus Negative Regulation Of Interleukin-2 Production Negative Regulation Of Cell Cycle Response To Radiation Histone H3-K9 Methylation Regulation Of Glucose Import In Response To Insulin Stimulus Inner Cell Mass Cell Proliferation Regulation Of Cholesterol Biosynthetic Process Histone-serine Phosphorylation Growth Negative Regulation Of Lipid Catabolic Process Cellular Response To Glucose Starvation Positive Regulation Of Protein Acetylation Peptidyl-lysine Trimethylation Response To Caffeine	Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity
Tagcloud ?			4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Difference) ?			4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Intersection) ?