PLEKHA4 and CCNG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PLEKHA4	CCNG1
Description		pleckstrin homology domain containing A4	cyclin G1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Identical Protein Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Division
Pathways		Synthesis of PIPs at the plasma membrane	Regulation of TP53 Degradation
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Aortic vascular smooth muscle cell proliferation in response to IL-1 beta ( 33040646) HIV progression (CD4 and viral load) ( 28132517) Metabolite levels ( 31628463) Plasma anti-thyroglobulin levels ( 29678681) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		9 interacting genes: ABL1 CCNG1 EEF1G KAT5 KLHL12 LRIF1 MEI4 SETDB1 SHANK3	28 interacting genes: APP CBY2 CCDC125 CDK5 CDKN2A DRC4 GAK GRN HMBOX1 KRT40 KRTAP10-7 LMNA LTBP3 LZTS2 MDM2 MT-CO2 NFATC4 PAK5 PLEKHA4 PNMA1 PPP2CA PTPA RBPMS SHKBP1 TFAP2C TFIP11 TNIP1 TP53
Entrez ID		57664	900
HPRD ID		09683	03345
Ensembl ID		ENSG00000105559	ENSG00000113328
Uniprot IDs		M0R0J1 Q9H4M7	P51959
PDB IDs		1UPQ 1UPR 8OIO
Enriched GO Terms of Interacting Partners?		Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Long-term Synaptic Potentiation Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Positive Regulation Of Neuron Apoptotic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Identical Protein Binding P53 Binding Disordered Domain Specific Binding Cellular Response To Actinomycin D Amyloid Fibril Formation Astrocyte Activation Involved In Immune Response Response To Actinomycin D Cellular Response To UV-C Regulation Of Proteolysis Regulation Of Protein Export From Nucleus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Negative Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Negative Regulation Of Multicellular Organismal Process Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Proteolysis Regulation Of Protein Localization To Nucleus Negative Regulation Of Cellular Component Organization Cellular Response To Antibiotic Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Response To Light Stimulus Negative Regulation Of Wnt Signaling Pathway Regulation Of Carbohydrate Catabolic Process MDM2/MDM4 Family Protein Binding Cellular Senescence Regulation Of Cell Population Proliferation Regulation Of Cellular Response To Stress Negative Regulation Of Cell Projection Organization Protein Localization To Nucleus Regulation Of Cell Cycle G1/S Phase Transition Response To UV-C Regulation Of Cellular Component Organization Regulation Of MiRNA Transcription Replicative Senescence Regulation Of Protein Stability
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