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PLEKHA4 and KAT5
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PLEKHA4
KAT5
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
K(lysine) acetyltransferase 5
Image
Gene Ontology Annotations
Cellular Component
Cellular_component
Cytoplasm
Membrane
Swr1 Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
Piccolo NuA4 Histone Acetyltransferase Complex
NuA4 Histone Acetyltransferase Complex
Perinuclear Region Of Cytoplasm
Molecular Function
1-phosphatidylinositol Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Protein Complex Binding
Metal Ion Binding
Androgen Receptor Binding
Repressing Transcription Factor Binding
Biological Process
Biological_process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Double-strand Break Repair
Chromatin Organization
Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Response To Ionizing Radiation
Viral Process
Histone Acetylation
Androgen Receptor Signaling Pathway
Negative Regulation Of Interleukin-2 Production
Regulation Of Growth
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Estradiol Stimulus
Positive Regulation Of Protein Acetylation
Pathways
Chromatin modifying enzymes
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
HATs acetylate histones
Drugs
Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS
Chronic kidney disease (
20383146
)
Protein-Protein Interactions
6 interactors:
CCNG1
EEF1G
KAT5
LRIF1
PRKAA1
SETDB1
136 interactors:
ALOX12
APBB1
APLP1
APLP2
APP
AR
ARIH2
ATM
ATXN1
BARD1
BCL3
BMI1
BRCA1
C1orf174
CBX8
CCDC106
CCDC136
CCNB1
CCT7
CDC42
CDK1
CDK5RAP2
CDKN2A
CREB1
CREBBP
CRELD1
CSTF2
DLEU1
DUSP23
E2F1
EDNRA
EFNA1
EP300
ESR1
ESR2
ETV6
FAM101B
FAM135B
FAM173A
GADD45G
GAPDH
GEMIN7
GET4
GMCL1
GMCL1P1
GOLGA2
GSTO1
H2AFX
H3F3B
HABP4
HAP1
HDAC1
HDAC7
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H3C
HIST2H4A
HIST3H3
HMBOX1
HNRNPH3
IK
IKZF3
IL9R
KIAA1377
KLF4
KRT40
KRTAP10-3
KRTAP10-9
LMNA
LONRF1
LRIF1
LRP1
LZTS2
MAD2L1BP
MAPRE1
MDFI
MDM2
MEOX2
MTUS2
MYC
MYOD1
NAP1L5
NDUFA4L2
NDUFV2
NFKB1
NINL
NR3C1
ODC1
OGFOD2
PDCD5
PHC2
PIH1D3
PITX2
PLA2G4A
PLEKHA4
PML
POLE2
POLR3F
PPARG
PTPN4
PTPRS
RB1
RCHY1
RELA
RGL2
RRM1
RRM2
SAT1
SNAPIN
SNRPD2
SOX5
SRF
SSX2IP
STAT3
STX11
SYN1
TBX5
TELO2
TMCC2
TNNT1
TP53
TRIB3
TRIM23
TRIM27
TRIM29
TRIM37
TUFT1
UHRF1
USP7
YWHAG
ZBTB14
ZBTB8A
ZEB1
ZNF24
ZNF513
Entrez ID
57664
10524
HPRD ID
09683
03245
Ensembl ID
ENSG00000105559
ENSG00000172977
Uniprot IDs
Q9H4M7
Q92993
PDB IDs
1UPQ
1UPR
2EKO
2OU2
Enriched GO Terms of Interacting Partners
?
Histone Modification
Negative Regulation Of Glucosylceramide Biosynthetic Process
Cold Acclimation
Chromatin Modification
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Chromatin Organization
Response To Ionizing Radiation
Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Response To Camptothecin
Transcription, DNA-templated
Peptidyl-amino Acid Modification
RNA Biosynthetic Process
Negative Regulation Of Sphingolipid Biosynthetic Process
Chromosome Organization
Peptidyl-lysine Modification
Biosynthetic Process
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Cholesterol Metabolic Process
Histone H3-K9 Trimethylation
Cellular Response To Ethanol
Negative Regulation Of Glucose Import
Regulation Of Energy Homeostasis
Positive Regulation Of Glycolytic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Negative Regulation Of Biosynthetic Process
DNA Damage Response, Signal Transduction Resulting In Transcription
Fatty Acid Homeostasis
Organelle Organization
RNA Metabolic Process
Negative Regulation Of Glucose Transport
Mitotic G2 DNA Damage Checkpoint
Cellular Response To Stress
Cellular Response To Estradiol Stimulus
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Cell Cycle
Response To Radiation
Histone H3-K9 Methylation
Regulation Of Glucose Import In Response To Insulin Stimulus
Inner Cell Mass Cell Proliferation
Regulation Of Cholesterol Biosynthetic Process
Histone-serine Phosphorylation
Growth
Negative Regulation Of Lipid Catabolic Process
Cellular Response To Glucose Starvation
Positive Regulation Of Protein Acetylation
Peptidyl-lysine Trimethylation
Response To Caffeine
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Transcription, DNA-templated
Gene Expression
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
RNA Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Developmental Process
Organ Development
Regulation Of Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Organization
Positive Regulation Of Metabolic Process
Mitotic Cell Cycle
Chromosome Organization
Anatomical Structure Development
Cellular Macromolecule Biosynthetic Process
System Development
Tissue Development
Cell Cycle
Macromolecule Biosynthetic Process
Regulation Of Cell Proliferation
Cell Death
Apoptotic Process
Death
Organelle Organization
Programmed Cell Death
Biosynthetic Process
Tagcloud
?
accumbens
brn2
decondensed
dmnt1
dnmt3a
erg1
exceptionally
fox3
foxg1
gadd45a
gadd45b
hdac11
homer1
kat2b
kat3a
kat3b
multilineage
multipotent
nef1
neg
neun
neurobiol
neurobiology
neuroplasticity
nfl
nuclei
periodicals
pons
syt1
Tagcloud (Difference)
?
accumbens
brn2
decondensed
dmnt1
dnmt3a
erg1
exceptionally
fox3
foxg1
gadd45a
gadd45b
hdac11
homer1
kat2b
kat3a
kat3b
multilineage
multipotent
nef1
neg
neun
neurobiol
neurobiology
neuroplasticity
nfl
nuclei
periodicals
pons
syt1
Tagcloud (Intersection)
?