PLEKHA4

Description		pleckstrin homology domain containing A4
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Identical Protein Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Novel Interacting Genes		1 novel interacting genes: ATP5MG
Interacting Genes		9 interacting genes: ABL1 CCNG1 EEF1G KAT5 KLHL12 LRIF1 MEI4 SETDB1 SHANK3
Entrez ID		57664
HPRD ID		09683
Ensembl ID		ENSG00000105559
Uniprot IDs		M0R0J1 Q9H4M7
PDB IDs		1UPQ 1UPR 8OIO
Enriched GO Terms of Interacting Partners?		Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Long-term Synaptic Potentiation Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
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