HACE1 and RAB4A

Number of citations of the paper that reports this interaction (PMID 21988917)
9

Data Source:
BioGRID (pull down)

		HACE1	RAB4A
Gene Name		HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	RAB4A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Golgi Cisterna Membrane	Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Rab GTPase Binding Rac GTPase Binding	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity GDP Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination	Intracellular Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Membrane Organization
Pathways			Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Height ( 18391951) Menarche (age at onset) ( 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Thyroid stimulating hormone ( 17903292)	Aging ( 22773346)
Protein-Protein Interactions		5 interactors: OPTN PLXNA2 RAB4A UBC UBE2L3	31 interactors: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GDI2 GRIPAP1 HACE1 IDH3A KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		57531	5867
HPRD ID		17086	01541
Ensembl ID		ENSG00000085382	ENSG00000168118
Uniprot IDs		Q8IYU2	P20338
PDB IDs			1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?		Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cerebellar Granule Cell Precursor Tangential Migration G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Hindbrain Tangential Cell Migration Membrane Organization Cellular Localization Protein Polyubiquitination Regulation Of Protein Ubiquitination Cell Cycle Process Negative Regulation Of Receptor Recycling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Golgi Ribbon Formation Antigen Processing And Presentation Cell Cycle Cellular Response To Stimulus Limb Bud Formation Viral Protein Processing Intracellular Transport Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pharyngeal System Development Notch Receptor Processing Protein K11-linked Ubiquitination Protein Targeting To Golgi Golgi To Plasma Membrane Protein Transport Cell Migration In Hindbrain Virion Assembly Response To Stimulus Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Establishment Of Localization In Cell Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Ubiquitination Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Receptor Recycling Protein Modification By Small Protein Conjugation Protein Catabolic Process Centrosome Localization	Membrane Organization Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Cell Cycle Transport Regulation Of Catalytic Activity Regulation Of Cellular Localization Organelle Organization Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Protein Targeting Endocytosis Mitotic Cell Cycle Process Response To Wounding Membrane Fusion Positive Regulation Of GTPase Activity Mitotic Cell Cycle Regulation Of GTPase Activity Regulation Of Protein Localization Mitotic Nuclear Division Intracellular Transport Regulation Of Cellular Component Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Intracellular Protein Transport Organelle Fusion Regulation Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Blood Coagulation Cellular Protein Localization Hemostasis Regulation Of Intracellular Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Hydrolase Activity Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Membrane Docking Mitotic DNA Damage Checkpoint Positive Regulation Of Transport Regulation Of Signal Transduction Intracellular Signal Transduction Mitotic DNA Integrity Checkpoint Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Component Assembly Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Metabolic Process
Tagcloud ?		adenine blocks confers constitutes dinucleotide e3 elevation example gtp gtpase hect holoenzyme hyper inactivation ligase nadph nicotinamide novo oxidase oxidases oxygen proteasomal rac1 reactive rho suppressor ubiquitylates vertebrates zebrafish	abnormally accessing anova cascades ckit decoupled dex dexamethasone ery erys erythroblast erythroblasts erythropoiesis escape expansion fdr gata1 gpr56 il3 pdgfrbeta polycythemia polycythemic pv repertoire scf tal1 tgfbeta tightly vera
Tagcloud (Difference) ?		adenine blocks confers constitutes dinucleotide e3 elevation example gtp gtpase hect holoenzyme hyper inactivation ligase nadph nicotinamide novo oxidase oxidases oxygen proteasomal rac1 reactive rho suppressor ubiquitylates vertebrates zebrafish	abnormally accessing anova cascades ckit decoupled dex dexamethasone ery erys erythroblast erythroblasts erythropoiesis escape expansion fdr gata1 gpr56 il3 pdgfrbeta polycythemia polycythemic pv repertoire scf tal1 tgfbeta tightly vera
Tagcloud (Intersection) ?