HACE1 and PLXNA2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		HACE1	PLXNA2
Gene Name		HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	plexin A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Golgi Cisterna Membrane	Semaphorin Receptor Complex Intracellular Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Rab GTPase Binding Rac GTPase Binding	Protein Binding Semaphorin Receptor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination	Somitogenesis Axon Guidance Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway
Pathways			Axon guidance Semaphorin interactions Other semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Height ( 18391951) Menarche (age at onset) ( 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Thyroid stimulating hormone ( 17903292)	Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		5 interactors: OPTN PLXNA2 RAB4A UBC UBE2L3	6 interactors: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L
Entrez ID		57531	5362
HPRD ID		17086	03033
Ensembl ID		ENSG00000085382	ENSG00000076356
Uniprot IDs		Q8IYU2	O75051
PDB IDs			3Q3J
Enriched GO Terms of Interacting Partners?		Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cerebellar Granule Cell Precursor Tangential Migration G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Hindbrain Tangential Cell Migration Membrane Organization Cellular Localization Protein Polyubiquitination Regulation Of Protein Ubiquitination Cell Cycle Process Negative Regulation Of Receptor Recycling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Golgi Ribbon Formation Antigen Processing And Presentation Cell Cycle Cellular Response To Stimulus Limb Bud Formation Viral Protein Processing Intracellular Transport Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pharyngeal System Development Notch Receptor Processing Protein K11-linked Ubiquitination Protein Targeting To Golgi Golgi To Plasma Membrane Protein Transport Cell Migration In Hindbrain Virion Assembly Response To Stimulus Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Establishment Of Localization In Cell Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Ubiquitination Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Receptor Recycling Protein Modification By Small Protein Conjugation Protein Catabolic Process Centrosome Localization	Positive Regulation Of Protein Kinase C Activity
Tagcloud ?		adenine blocks confers constitutes dinucleotide e3 elevation example gtp gtpase hect holoenzyme hyper inactivation ligase nadph nicotinamide novo oxidase oxidases oxygen proteasomal rac1 reactive rho suppressor ubiquitylates vertebrates zebrafish
Tagcloud (Difference) ?		adenine blocks confers constitutes dinucleotide e3 elevation example gtp gtpase hect holoenzyme hyper inactivation ligase nadph nicotinamide novo oxidase oxidases oxygen proteasomal rac1 reactive rho suppressor ubiquitylates vertebrates zebrafish
Tagcloud (Intersection) ?