HACE1

Description		HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Body Golgi Cisterna Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Small GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Membrane Fusion Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 27182965 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		10 interacting genes: CCNC MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		57531
HPRD ID		17086
Ensembl ID		ENSG00000085382
Uniprot IDs		Q8IYU2
PDB IDs		8H8X 8HAE 8PWL 8Q0N
Enriched GO Terms of Interacting Partners?		Hepatocyte Growth Factor Receptor Signaling Pathway Recycling Endosome Membrane Regulation Of Fibroblast Migration Positive Regulation Of Microtubule Polymerization Semaphorin-plexin Signaling Pathway Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Positive Regulation Of Stress Fiber Assembly Actin Filament Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Actin Filament Bundle Assembly Cerebellar Granule Cell Precursor Tangential Migration G Protein Activity Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Nucleotide Binding Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Stress Fiber Assembly Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis
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