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HACE1
Gene Name
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Nucleus
Endoplasmic Reticulum
Golgi Cisterna Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Rab GTPase Binding
Rac GTPase Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Golgi Organization
Cell Cycle
Protein Ubiquitination
Rac Protein Signal Transduction
Regulation Of Cell Migration
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Membrane Fusion
Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS
Height (
18391951
)
Menarche (age at onset) (
19448622
)
Multiple sclerosis (
23412934
)
Neuroblastoma (
22941191
)
Obsessive-compulsive disorder (
22889921
)
Thyroid stimulating hormone (
17903292
)
Protein-protein Interactions
5 interactors:
OPTN
PLXNA2
RAB4A
UBC
UBE2L3
Entrez ID
57531
HPRD ID
17086
Ensembl ID
ENSG00000085382
Uniprot IDs
Q8IYU2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Cerebellar Granule Cell Precursor Tangential Migration
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Ubiquitination
Hindbrain Tangential Cell Migration
Membrane Organization
Cellular Localization
Protein Polyubiquitination
Regulation Of Protein Ubiquitination
Cell Cycle Process
Negative Regulation Of Receptor Recycling
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Mitotic Cell Cycle Phase Transition
Golgi Ribbon Formation
Antigen Processing And Presentation
Cell Cycle
Cellular Response To Stimulus
Limb Bud Formation
Viral Protein Processing
Intracellular Transport
Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Pharyngeal System Development
Notch Receptor Processing
Protein K11-linked Ubiquitination
Protein Targeting To Golgi
Golgi To Plasma Membrane Protein Transport
Cell Migration In Hindbrain
Virion Assembly
Response To Stimulus
Establishment Of Protein Localization To Golgi
Retrograde Transport, Vesicle Recycling Within Golgi
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Establishment Of Localization In Cell
Positive Regulation Of Transferase Activity
Cellular Protein Catabolic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein Ubiquitination
Glycogen Biosynthetic Process
Intracellular Transport Of Virus
Regulation Of Receptor Recycling
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Centrosome Localization
Tagcloud
?
adenine
blocks
confers
constitutes
dinucleotide
e3
elevation
example
gtp
gtpase
hect
holoenzyme
hyper
inactivation
ligase
nadph
nicotinamide
novo
oxidase
oxidases
oxygen
proteasomal
rac1
reactive
rho
suppressor
ubiquitylates
vertebrates
zebrafish