HACE1 and OPTN

Number of citations of the paper that reports this interaction (PMID 25026213)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		HACE1	OPTN
Gene Name		HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	optineurin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Golgi Cisterna Membrane	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Rab GTPase Binding Rac GTPase Binding	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation
Pathways			G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 18391951) Menarche (age at onset) ( 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Thyroid stimulating hormone ( 17903292)	Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		5 interactors: OPTN PLXNA2 RAB4A UBC UBE2L3	36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670
Entrez ID		57531	10133
HPRD ID		17086	03891
Ensembl ID		ENSG00000085382	ENSG00000123240
Uniprot IDs		Q8IYU2	Q96CV9
PDB IDs			2LO4 2LUE 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cerebellar Granule Cell Precursor Tangential Migration G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Hindbrain Tangential Cell Migration Membrane Organization Cellular Localization Protein Polyubiquitination Regulation Of Protein Ubiquitination Cell Cycle Process Negative Regulation Of Receptor Recycling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Golgi Ribbon Formation Antigen Processing And Presentation Cell Cycle Cellular Response To Stimulus Limb Bud Formation Viral Protein Processing Intracellular Transport Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pharyngeal System Development Notch Receptor Processing Protein K11-linked Ubiquitination Protein Targeting To Golgi Golgi To Plasma Membrane Protein Transport Cell Migration In Hindbrain Virion Assembly Response To Stimulus Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Establishment Of Localization In Cell Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Ubiquitination Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Receptor Recycling Protein Modification By Small Protein Conjugation Protein Catabolic Process Centrosome Localization	Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction
Tagcloud ?		adenine blocks confers constitutes dinucleotide e3 elevation example gtp gtpase hect holoenzyme hyper inactivation ligase nadph nicotinamide novo oxidase oxidases oxygen proteasomal rac1 reactive rho suppressor ubiquitylates vertebrates zebrafish	advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Difference) ?		adenine blocks confers constitutes dinucleotide e3 elevation example gtp gtpase hect holoenzyme hyper inactivation ligase nadph nicotinamide novo oxidase oxidases oxygen proteasomal rac1 reactive rho suppressor ubiquitylates vertebrates zebrafish	advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Intersection) ?