DVL3 and TCEA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DVL3	TCEA2
Description		dishevelled segment polarity protein 3	transcription elongation factor A2
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GO Annotations	Cellular Component	Chromatin Cytoplasm Cytosol	Nucleus Nucleoplasm Centrosome Transcription Elongation Factor Complex Ciliary Basal Body
	Molecular Function	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Small GTPase-mediated Signal Transduction Response To Xenobiotic Stimulus Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Neuron Projection Arborization	DNA-templated Transcription DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Adult body size ( 32376654) Adventurousness ( 30643258) Alanine aminotransferase levels ( 34315874) Anxiety ( 31906708) Aspartate aminotransferase levels ( 34315874) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil count ( 32888494) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Pulse pressure ( 30578418 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Systolic blood pressure ( 27841878) Triglyceride levels ( 29083408) Type 2 diabetes (adjusted for BMI) ( 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		166 interacting genes: ABT1 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 DYRK1A EIF1B EIF3D ENKD1 FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 MBD1 NFYA NKD1 NOL12 NXF1 PATZ1 PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RBM15B RBM39 RNF151 RPL11 RPS10 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25	134 interacting genes: ADAMTSL4 AGR2 AGTRAP AKT1S1 ALAS1 AMOTL2 APP ARMC10 AXIN2 BACH2 BICD2 BOLL BRCA1 BTBD6 CAMKV CBY2 CCDC136 CCDC157 CCSER2 CDK11B CENPT CEP44 CEP70 CEP76 CMTM4 CMTM6 CNTROB COX20 CYSRT1 DAB1 DCAF10 DES DHRS2 DNAJB9 DRC4 DVL3 EAF1 EAF2 ERBB3 EXOSC8 FADD FAM9B FBF1 FCHO1 FXR1 GIGYF1 GOLGA2 GPKOW GPRASP3 GRIPAP1 GTF2B HES7 HIGD1C HIP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 IKZF4 KCNF1 KCTD10 KCTD7 KIAA1958 KRT40 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP5-9 KXD1 LIMS1 LMNA LRRK2 LZTS1 LZTS2 MAGEA11 MARK3 MCC MCM2 MDK MEOX2 MID2 MKRN3 MSANTD4 MTUS2 NAB2 NECAB1 NECAB2 OSBPL3 PIBF1 PICK1 PIH1D2 PNMA1 PNMA5 POU6F2 PRPH RBPMS RETREG3 RPA1 SCYL1 SH3GL2 SSC5D STAC3 STX11 SYNE4 TARBP2 TAX1BP1 TAX1BP3 TBC1D1 TCF4 TEPSIN TFCP2 THAP1 TMEM71 TNIP1 TOX2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM38 TRIM41 TRIM54 TSGA10 USP54 VIM WDR47 ZBTB22 ZBTB43 ZBTB8A ZBTB9 ZKSCAN8 ZNF526
Entrez ID		1857	6919
HPRD ID		03222	16069
Ensembl ID		ENSG00000161202	ENSG00000171703
Uniprot IDs		Q92997	Q15560 Q6IB64
PDB IDs		6V7O 6ZBQ 6ZBZ 6ZC3 6ZC4 6ZC6 6ZC7 6ZC8 8S6A	2LW4
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Wnt Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Cellular Response To Endothelin Response To Endothelin Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Epigenetic Regulation Of Gene Expression Wnt Signalosome Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Chromatin Organization Nucleic Acid Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sequence-specific Double-stranded DNA Binding Heterochromatin Formation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Chromatin Remodeling U2-type Precatalytic Spliceosome Chromatin Silencing Complex Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Identical Protein Binding Protein Binding Intermediate Filament Cytosol
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