DVL3 and ZBTB48

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		DVL3	ZBTB48
Gene Name		dishevelled segment polarity protein 3	zinc finger and BTB domain containing 48
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697	17 interactors: C11orf58 C7orf34 CDK2AP2 CDKN1A DVL3 EP300 GPATCH2L ILK KRTAP10-5 NME7 NUDT21 PNRC2 RGS2 TNFRSF14 UPF2 ZBTB7A ZBTB8A
Entrez ID		1857	3104
HPRD ID		03222	01316
Ensembl ID		ENSG00000161202	ENSG00000204859
Uniprot IDs		Q92997	A8K291 B2R702 P10074
PDB IDs			3B84
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly	Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Transferase Activity Regulation Of Protein Metabolic Process Cellular Response To Heat Histone H2B Acetylation Negative Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Cell Aging Organ Regeneration Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Phosphorylation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Response To Heat Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Tubulin Deacetylation Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Intestinal Epithelial Cell Maturation Non-canonical Wnt Signaling Pathway Via JNK Cascade MRNA Metabolic Process Cell Cycle Arrest Nuclear-transcribed MRNA Catabolic Process Organ Development Positive Regulation Of Transferase Activity Positive Regulation Of Wnt Signaling Pathway Developmental Process Regulation Of Adrenergic Receptor Signaling Pathway
Tagcloud ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?