DANCR and PKM

Number of citations of the paper that reports this interaction (PubMedID 31863900)
0

Data Source:
BioGRID (unspecified method)

		DANCR	PKM
Description		differentiation antagonizing non-protein coding RNA	pyruvate kinase M1/2
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function		Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Activity RNA Binding MRNA Binding Catalytic Activity Protein Tyrosine Kinase Activity Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Histone H3T11 Kinase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding
	Biological Process		Glycolytic Process Chromatin Remodeling Regulation Of Translation Programmed Cell Death Cellular Response To Insulin Stimulus Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation
Pathways			Neutrophil degranulation Negative Regulation of CDH1 Gene Transcription
Drugs			Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Indoprofen Copper Polydatin Artenimol
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301)
Interacting Genes		20 interacting genes: AP1G2 ARF5 CAV1 EZH2 FOXO1 G3BP2 GLRX3 HNRNPA1 KRT9 NCL NONO PKM PSPC1 RBM25 SERBP1 SRSF1 SYT1 TPM4 YBX1 YBX3	71 interacting genes: ANXA7 APP ARAF ARX AURKB CCR4 CDC25A CDK4 CEBPA CLIC6 CTNNB1 DANCR DDX39B DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 FXR1 FXR2 GRB7 HERC1 HIF1A HOXA1 HSP90AA1 HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MBNL1 MDM2 MECOM MYL2 MYOC NAGK NDRG1 NXT2 OGT OLFM2 OTUB2 PAX8 PDE4B PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 STUB1 SUMO1 SUMO2 TERF1 TINF2 TK1 TP53 TRIM35 TRIM63 UBE3A UCHL5 USP7 YWHAQ
Entrez ID		57291	5315
HPRD ID			01529
Ensembl ID		ENSG00000226950	ENSG00000067225
Uniprot IDs			A0A804F6T5 A0A804F729 A0A8V8TNX9 B4DNK4 P14618 V9HWB8
PDB IDs			1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6 7L21 8G2E 8HGF 8HMQ 8HMR 8HMS 8HMU 8X4R
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding RNA Binding Regulation Of MRNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Binding Regulation Of Cytoplasmic Translation MRNA Binding Cellular Response To Hyperoxia Regulation Of RNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Transport Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Peptide Hormone Stimulus RNA Splicing Regulation Of RNA Splicing Paraspeckles Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Increased Oxygen Levels Negative Regulation Of RNA Metabolic Process Nucleobase-containing Compound Transport Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability RNA Stabilization MRNA Processing Regulation Of Protein Metabolic Process Negative Regulation Of RNA Catabolic Process Response To Hyperoxia Negative Regulation Of Necroptotic Process Negative Regulation Of MRNA Metabolic Process Cellular Response To Chemical Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Circadian Rhythm Response To Peptide Hormone Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Regulation Of The Force Of Heart Contraction Negative Regulation Of DNA-templated Transcription MRNA 3'-UTR Binding MRNA Transport	Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Telomere Maintenance Regulation Of Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Signal Transduction Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Signaling Cassette Nucleoplasm Response To Xenobiotic Stimulus Glutamatergic Synapse Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process ERBB Signaling Pathway Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle
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