RBBP8 and TMEM54

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RBBP8	TMEM54
Gene Name		retinoblastoma binding protein 8	transmembrane protein 54
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcriptional Repressor Complex	Cellular_component Integral Component Of Membrane
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Damaged DNA Binding Protein Binding	Molecular_function
	Biological Process	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic Blastocyst Hatching DNA Repair Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing G2 DNA Damage Checkpoint Cell Division Meiotic Cell Cycle	Biological_process
Pathways		Meiotic recombination
Drugs
Diseases
GWAS		Height ( 18391951) Intracranial aneurysm ( 20364137) Tuberculosis ( 20694014)
Protein-Protein Interactions		34 interactors: ATM BARD1 BRCA1 CLU CTBP1 CTBP2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 LIMS1 LMO1 LMO2 LMO4 MAP2K4 MRE11A PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 WDYHV1	2 interactors: PEX19 RBBP8
Entrez ID		5932	113452
HPRD ID		04990	12524
Ensembl ID		ENSG00000101773	ENSG00000121900
Uniprot IDs		Q99708	Q969K7
PDB IDs		2L4Z
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process G2 DNA Damage Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Cell Death Cell Cycle Checkpoint Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Phosphorylation Cell Death Negative Regulation Of Gene Expression Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Protein Modification Process Telomere Maintenance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Immune System Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Double-strand Break Repair Via Homologous Recombination Recombinational Repair	Negative Regulation Of Lipid Binding DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport DNA Double-strand Break Processing Peroxisomal Membrane Transport Blastocyst Hatching Peroxisome Fission Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Membrane Biogenesis G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Chaperone-mediated Protein Folding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Protein Stabilization Blastocyst Development Negative Regulation Of Binding Regulation Of Protein Stability DNA Catabolic Process Double-strand Break Repair DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Protein Import Protein Targeting To Membrane
Tagcloud ?		advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Difference) ?		advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Intersection) ?