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RBBP8 and BARD1
Number of citations of the paper that reports this interaction (PubMedID
10764811
)
0
Data Source:
HPRD
(in vitro, in vivo)
RBBP8
BARD1
Description
RB binding protein 8, endonuclease
BRCA1 associated RING domain 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Transcription Repressor Complex
Site Of Double-strand Break
BRCA1-C Complex
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
Molecular Function
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
Damaged DNA Binding
Transcription Corepressor Activity
Nuclease Activity
Endonuclease Activity
Protein Binding
Hydrolase Activity
Identical Protein Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Blastocyst Hatching
DNA Repair
DNA Damage Response
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Homologous Recombination
Mitotic G2/M Transition Checkpoint
Negative Regulation Of DNA-templated Transcription
Cell Division
Meiotic Cell Cycle
DNA Strand Resection Involved In Replication Fork Processing
Tissue Homeostasis
DNA Repair
Regulation Of DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Homologous Recombination
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Protein Export From Nucleus
Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Damage Checkpoint
Pathways
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Seckel syndrome
GWAS
Eosinophil percentage of white cells (
27863252
)
Estradiol levels (
34255042
)
Height (
18391951
25429064
)
Hip circumference adjusted for BMI (
34021172
)
Intracranial aneurysm (
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Late-onset myasthenia gravis (
26562150
)
Lung function (FEV1) (
30061609
)
Lymphocyte count (
32888494
)
Scalp hair shape (
26926045
)
Tuberculosis (
20694014
)
Waist circumference adjusted for body mass index (
34021172
)
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
21124317
22941191
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Interacting Genes
40 interacting genes:
ATM
BARD1
BRCA1
CLU
CTBP1
CUL3
DNA2
FXR2
FZR1
HID1
IGFBP7
IKBKG
IKZF1
IKZF3
KLHL15
LIMS1
LMO1
LMO2
LMO4
MAP2K4
NTAQ1
PAN2
PCNA
PELI2
PIAS4
PIN1
PRRG4
RAF1
RB1
RBL1
RBL2
RGS17
RNF4
SIAH1
SIAH2
TGIF2
TMEM54
TOPBP1
UBE2I
USP4
131 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BGLT3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCAF8L2
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AC4
H2BC3
H3C1
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LARP7
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKB1
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RNF10
RPS20
SELENBP1
SETDB1
SKIC8
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
Entrez ID
5932
580
HPRD ID
04990
03354
Ensembl ID
ENSG00000101773
ENSG00000138376
Uniprot IDs
Q99708
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
PDB IDs
1Y98
2L4Z
4D2H
7BGF
1JM7
2NTE
2R1Z
3C5R
3FA2
6M14
7E8I
7JZV
7LYB
7LYC
8GRQ
Enriched GO Terms of Interacting Partners
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Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Positive Regulation Of Metabolic Process
Protein Modification Process
BRCA1-B Complex
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Protein Ubiquitination
Mitotic G2 DNA Damage Checkpoint Signaling
Ubiquitin Protein Ligase Activity
Positive Regulation Of Protein Metabolic Process
Homologous Recombination
Nucleoplasm
Regulation Of Apoptotic Signaling Pathway
Protein Polyubiquitination
DNA Strand Resection Involved In Replication Fork Processing
DNA Damage Response
Nucleoplasm
DNA Repair
Ubiquitin Conjugating Enzyme Activity
DNA Metabolic Process
Chromosome
Nucleus
Chromatin Organization
Nucleic Acid Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Enzyme Binding
Modification-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Maintenance Of DNA Repeat Elements
Heterochromatin Formation
Negative Regulation Of DNA Recombination
Chromatin Binding
Protein Monoubiquitination
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Single Guanine Insertion Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Ubiquitin-protein Transferase Activity
Negative Regulation Of Gene Expression, Epigenetic
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