RBBP8 and IGFBP7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RBBP8	IGFBP7
Description		RB binding protein 8, endonuclease	insulin like growth factor binding protein 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Receptor Ligand Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing	Angiogenesis Regulation Of Cell Growth Cell Adhesion Signal Transduction Embryo Implantation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Steroid Biosynthetic Process Response To Cortisol Cellular Response To Prostaglandin E Stimulus
Pathways		HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Insulin human
Diseases		Seckel syndrome
GWAS		Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)	Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Schizophrenia x sex interaction ( 34099189) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4	11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		5932	3490
HPRD ID		04990	04183
Ensembl ID		ENSG00000101773	ENSG00000163453
Uniprot IDs		Q99708	Q16270
PDB IDs		1Y98 2L4Z 4D2H 7BGF	8IVD
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing	Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Cytokine Activity Granulocyte Chemotaxis Regulation Of T Cell Chemotaxis Extracellular Region Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Insulin Receptor Binding Extracellular Space Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Migration Regulation Of Secretion By Cell Hormone Activity Positive Regulation Of Cell Motility Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Glycogen Biosynthetic Process Regulation Of Secretion Receptor Ligand Activity Myeloid Leukocyte Migration Chemoattractant Activity Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Leukocyte Chemotaxis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Glycogen Metabolic Process Growth Factor Activity Regulation Of Cell Cycle Process Positive Regulation Of Lymphocyte Migration Positive Chemotaxis Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of T Cell Migration Chemokine Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Epithelial Cell Proliferation Cell Chemotaxis Regulation Of Apoptotic Process
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