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RBBP8 and HID1
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
RBBP8
HID1
Description
RB binding protein 8, endonuclease
HID1 domain containing
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Transcription Repressor Complex
Site Of Double-strand Break
BRCA1-C Complex
Golgi Trans Cisterna
Golgi Membrane
Cytoplasm
Golgi Apparatus
Golgi Medial Cisterna
Cytosol
Cytoplasmic Microtubule
Membrane
Extracellular Exosome
Cytoplasmic Side Of Golgi Membrane
Molecular Function
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
Damaged DNA Binding
Transcription Corepressor Activity
Nuclease Activity
Endonuclease Activity
Protein Binding
Hydrolase Activity
Identical Protein Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Blastocyst Hatching
DNA Repair
DNA Damage Response
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Homologous Recombination
Mitotic G2/M Transition Checkpoint
Negative Regulation Of DNA-templated Transcription
Cell Division
Meiotic Cell Cycle
DNA Strand Resection Involved In Replication Fork Processing
Response To Glucose
Insulin Processing
Vacuole Fusion, Non-autophagic
Secretory Granule Maturation
Pathways
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Seckel syndrome
GWAS
Eosinophil percentage of white cells (
27863252
)
Estradiol levels (
34255042
)
Height (
18391951
25429064
)
Hip circumference adjusted for BMI (
34021172
)
Intracranial aneurysm (
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Late-onset myasthenia gravis (
26562150
)
Lung function (FEV1) (
30061609
)
Lymphocyte count (
32888494
)
Scalp hair shape (
26926045
)
Tuberculosis (
20694014
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
40 interacting genes:
ATM
BARD1
BRCA1
CLU
CTBP1
CUL3
DNA2
FXR2
FZR1
HID1
IGFBP7
IKBKG
IKZF1
IKZF3
KLHL15
LIMS1
LMO1
LMO2
LMO4
MAP2K4
NTAQ1
PAN2
PCNA
PELI2
PIAS4
PIN1
PRRG4
RAF1
RB1
RBL1
RBL2
RGS17
RNF4
SIAH1
SIAH2
TGIF2
TMEM54
TOPBP1
UBE2I
USP4
13 interacting genes:
BEGAIN
CBS
CELF3
CSDE1
EHHADH
INPPL1
NLGN3
RAD51
RBBP8
RCN3
TRIM55
TRIM63
UBL5
Entrez ID
5932
283987
HPRD ID
04990
05766
Ensembl ID
ENSG00000101773
ENSG00000167861
Uniprot IDs
Q99708
Q8IV36
PDB IDs
1Y98
2L4Z
4D2H
7BGF
Enriched GO Terms of Interacting Partners
?
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Positive Regulation Of Metabolic Process
Protein Modification Process
BRCA1-B Complex
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Protein Ubiquitination
Mitotic G2 DNA Damage Checkpoint Signaling
Ubiquitin Protein Ligase Activity
Positive Regulation Of Protein Metabolic Process
Homologous Recombination
Nucleoplasm
Regulation Of Apoptotic Signaling Pathway
Protein Polyubiquitination
DNA Strand Resection Involved In Replication Fork Processing
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Tagcloud (Intersection)
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