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PNO1 and PDPK1
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
PNO1
PDPK1
Gene Name
partner of NOB1 homolog (S. cerevisiae)
3-phosphoinositide dependent protein kinase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Cytoplasmic Membrane-bounded Vesicle
Cell Projection
Molecular Function
Poly(A) RNA Binding
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Insulin Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Protein Kinase Binding
Phospholipase Binding
Biological Process
Type B Pancreatic Cell Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Transmission
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Regulation Of Endothelial Cell Migration
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Activation Of Protein Kinase B Activity
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mast Cell Degranulation
Innate Immune Response
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Focal Adhesion Assembly
T Cell Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Extrinsic Apoptotic Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Signaling by FGFR in disease
Activation of PKB
Platelet Aggregation (Plug Formation)
Signaling by EGFRvIII in Cancer
CREB phosphorylation through the activation of Ras
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
FCERI mediated NF-kB activation
PI3K/AKT activation
PI-3K cascade
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
G-protein beta:gamma signalling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
TCR signaling
Signaling by VEGF
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Platelet activation, signaling and aggregation
Adaptive Immune System
Transmission across Chemical Synapses
Downstream TCR signaling
Activation of PKB
Costimulation by the CD28 family
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
VEGFR2 mediated cell proliferation
G beta:gamma signalling through PI3Kgamma
PI3K events in ERBB2 signaling
RSK activation
Downstream signaling of activated FGFR
VEGFR2 mediated vascular permeability
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Signaling by Insulin receptor
Innate Immune System
Post NMDA receptor activation events
Signalling by NGF
Insulin receptor signalling cascade
CTLA4 inhibitory signaling
Integrin alphaIIb beta3 signaling
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
GPVI-mediated activation cascade
PI3K Cascade
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
Staurosporine
Rbt205 Inhibitor
Phosphonoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
ATP5C1
CSNK1E
FRZB
GSTP1
IGFBP5
KLF6
PDPK1
RXRG
SGSM2
SUPT5H
58 interactors:
AKT1
AKT2
AKT3
AKTIP
APP
BLMH
C2orf44
CARD11
CDAN1
DDIT4
FAM213B
GIT1
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
LUC7L2
MAPK8
MTOR
PAK1
PEA15
PHAX
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SLC9A3R2
SMARCB1
SOCS3
SRC
SRPK1
STRAP
TCAP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
Entrez ID
56902
5170
HPRD ID
14250
05556
Ensembl ID
ENSG00000115946
ENSG00000140992
Uniprot IDs
Q9NRX1
E9PER6
O15530
PDB IDs
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Hepatocyte Differentiation
Nitric Oxide Storage
Cellular Response To Organic Substance
Regulation Of Signaling
Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Cellular Nitrogen Compound Metabolic Process
Nitric Oxide Homeostasis
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Skeletal Muscle Tissue Growth
Late Endosome To Golgi Transport
Skeletal Muscle Tissue Development
Common Myeloid Progenitor Cell Proliferation
Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Skeletal Muscle Organ Development
Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Proliferation
Convergent Extension Involved In Organogenesis
Mammary Gland Involution
Negative Regulation Of Wnt Signaling Pathway
System Development
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Superoxide Anion Generation
Negative Regulation Of Cellular Protein Metabolic Process
Tissue Development
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Kinase Activity
Response To Stimulus
Regulation Of Intracellular Signal Transduction
Organ Development
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of JUN Kinase Activity
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Type B Pancreatic Cell Proliferation
Wnt Signaling Pathway
Muscle Organ Development
Regulation Of Cellular Component Organization
Regulation Of Superoxide Anion Generation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Protein Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Apoptotic Process
Programmed Cell Death
Regulation Of Signaling
Intracellular Signal Transduction
Cell Death
Death
Innate Immune Response
Cellular Protein Modification Process
Response To Stress
Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Glucose Import
Regulation Of Glucose Transport
Phosphate-containing Compound Metabolic Process
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Cell Motility
Defense Response
Regulation Of Protein Phosphorylation
Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Immune Response-regulating Signaling Pathway
Regulation Of Cellular Component Movement
Cellular Response To Peptide Hormone Stimulus
Negative Regulation Of Insulin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Metabolic Process
Cellular Response To Peptide
Cellular Response To Organic Substance
Signal Transduction
Cellular Response To Stimulus
Peptidyl-threonine Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Platelet Activation
Tagcloud
?
amplified
bcl2l1
caspase
caspases
executioner
ikbkb
kinome
mb231
mb468
mesenchymal
nodes
nonkinases
phosphatases
phosphatome
r1
r2
regulators
representing
screens
sensitivities
sensitizes
sineg
sirna
skbr3
src
subset
t47d
tnbc
trail
Tagcloud (Difference)
?
amplified
bcl2l1
caspase
caspases
executioner
ikbkb
kinome
mb231
mb468
mesenchymal
nodes
nonkinases
phosphatases
phosphatome
r1
r2
regulators
representing
screens
sensitivities
sensitizes
sineg
sirna
skbr3
src
subset
t47d
tnbc
trail
Tagcloud (Intersection)
?