PNO1 and PDPK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PNO1	PDPK1
Description		partner of NOB1 homolog	3-phosphoinositide dependent protein kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytoplasmic Vesicle Cell Projection Anchoring Junction
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity 3-phosphoinositide-dependent Protein Kinase Activity Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Phospholipase Binding Protein Serine Kinase Activity
	Biological Process	Ribosomal Small Subunit Biogenesis	Type B Pancreatic Cell Development Protein Phosphorylation Hyperosmotic Response Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Calcium-mediated Signaling Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signaling Cassette Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Activation of AKT2 Downstream TCR signaling Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated NF-kB activation Integrin signaling CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma RSK activation VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases activate PKNs Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Celecoxib Inositol 1,3,4,5-Tetrakisphosphate 7-Hydroxystaurosporine Bisindolylmaleimide VIII Staurosporine Bisindolylmaleimide I Dexfosfoserine 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE Fostamatinib
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: ATP5F1C FRZB GSTP1 IGFBP5 KLF6 PDPK1 PICK1 RXRG SGSM2 SUPT5H	68 interacting genes: AKT1 AKT2 AKT3 AKTIP APBB3 APP BLMH CARD11 CDAN1 CSK CSNK1D CUL3 DDIT4 GIT1 GSK3B HSP90AA1 ILK IRS1 ITGB3 KATNBL1 KLHL20 LUC7L2 MAPK8 MTOR NHERF2 PAK1 PEA15 PHAX PIK3C3 PKN1 PKN2 PNO1 POLDIP2 PRKACA PRKCB PRKCD PRKCE PRKCI PRKCZ PRSS23 PRXL2B PTK2B PXN RALGDS RPS6KA1 RPS6KA3 RPS6KB1 RPS6KB2 SBF1 SGK1 SGK2 SGK3 SMARCB1 SOCS3 SPOP SRC SRPK1 STRAP TCAP UBC UBE2I WDCP XPO7 XRCC6 YWHAH YWHAQ ZC3HC1 ZNF133
Entrez ID		56902	5170
HPRD ID		14250	05556
Ensembl ID		ENSG00000115946	ENSG00000140992
Uniprot IDs		Q9NRX1	E9PER6 O15530
PDB IDs		6G18 6G4S 6G4W 6G51 6G53 6G5I 6ZUO 6ZXD 6ZXE 7MQ8 7MQ9 7MQA 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 8ZDC 8ZDD	1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3NUN 3NUS 3NUU 3NUY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1 4CT1 4CT2 4RQK 4RQV 4RRV 4XX9 5ACK 5HKM 5HNG 5HO7 5HO8 5LVL 5LVM 5LVN 5LVO 5LVP 5MRD 6WJQ 8DQT
Enriched GO Terms of Interacting Partners?		Cellular Developmental Process Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Growth Cell Development Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Dinitrosyl-iron Complex Binding S-nitrosoglutathione Binding Response To Epidermal Growth Factor Nitric Oxide Storage Negative Regulation Of Muscle Hypertrophy Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Skeletal Muscle Hypertrophy 3-phosphoinositide-dependent Protein Kinase Activity Glial Cell Development Regulation Of Cartilage Development Regulation Of Smooth Muscle Cell Migration Response To Peptide Hormone Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion TRAF2-GSTP1 Complex DSIF Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Insulin Stimulus Regulation Of Cell Growth Insulin-like Growth Factor Binding Protein Complex Regulation Of Cell Population Proliferation Regulation Of Cell Migration Glutathione Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Insulin-like Growth Factor Ternary Complex Membrane Curvature Sensor Activity Epithelial Cell Development Convergent Extension Involved In Organogenesis Regulation Of Cell Motility Negative Regulation Of Smooth Muscle Cell Chemotaxis Nitric Oxide Binding Response To L-ascorbic Acid Mammary Gland Involution Positive Regulation Of Sarcomere Organization	Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Phosphorylation Phosphorylation Intracellular Signal Transduction ATP Binding Protein Modification Process Cytosol Cellular Response To Peptide Hormone Stimulus Nucleotide Binding Cellular Response To Oxygen-containing Compound Protein Metabolic Process Cellular Response To Hormone Stimulus Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Nucleus TOR Signaling Transferase Activity TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Response To Peptide Hormone Negative Regulation Of Cellular Response To Insulin Stimulus Response To Hormone Phosphate-containing Compound Metabolic Process Signal Transduction Regulation Of Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Insulin Stimulus Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Regulation Of TOR Signaling Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Fluid Shear Stress Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction
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