PNO1 and SUPT5H

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PNO1	SUPT5H
Gene Name		partner of NOB1 homolog (S. cerevisiae)	suppressor of Ty 5 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Poly(A) RNA Binding	Chromatin Binding Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Cell Cycle Response To Organic Substance Gene Expression Viral Process Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways			Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat mRNA Capping HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATP5C1 CSNK1E FRZB GSTP1 IGFBP5 KLF6 PDPK1 RXRG SGSM2 SUPT5H	37 interactors: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CSNK2A1 DBN1 DCAF6 GTF3C1 H2AFX HTATSF1 IK IKBKG LMAN2 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUPT4H1 TERF1 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		56902	6829
HPRD ID		14250	03655
Ensembl ID		ENSG00000115946	ENSG00000196235
Uniprot IDs		Q9NRX1	O00267
PDB IDs			2DO3 2E6Z 2E70 3H7H 4L1U
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Hepatocyte Differentiation Nitric Oxide Storage Cellular Response To Organic Substance Regulation Of Signaling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Cellular Nitrogen Compound Metabolic Process Nitric Oxide Homeostasis Negative Regulation Of Monocyte Chemotactic Protein-1 Production Skeletal Muscle Tissue Growth Late Endosome To Golgi Transport Skeletal Muscle Tissue Development Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Skeletal Muscle Organ Development Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Convergent Extension Involved In Organogenesis Mammary Gland Involution Negative Regulation Of Wnt Signaling Pathway System Development Negative Regulation Of Protein Kinase Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Cellular Protein Metabolic Process Tissue Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Kinase Activity Response To Stimulus Regulation Of Intracellular Signal Transduction Organ Development Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Apoptotic Process Type B Pancreatic Cell Proliferation Wnt Signaling Pathway Muscle Organ Development Regulation Of Cellular Component Organization Regulation Of Superoxide Anion Generation	Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Cellular Macromolecule Biosynthetic Process Regulation Of Viral Transcription Macromolecule Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription From RNA Polymerase II Promoter Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Metabolic Process Cell Cycle Cellular Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Negative Regulation Of Gene Expression, Epigenetic Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter
Tagcloud ?			19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Difference) ?			19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Intersection) ?