PSAP and UBE3A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PSAP	UBE3A
Gene Name		prosaposin	ubiquitin protein ligase E3A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Nucleolus Mitochondrion Lysosomal Membrane Golgi Apparatus Integral Component Of Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Enzyme Activator Activity Lipid Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Platelet Degranulation Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Lipid Transport Blood Coagulation Regulation Of Lipid Metabolic Process Platelet Activation Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Small Molecule Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Cellular Response To Organic Substance	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Peptide ligand-binding receptors Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: BACE1 BRCA1 CD1B CELSR1 COPS6 CTSD GBA MAFF SGK223 SMAD2 SMAD9 UBE3A USP4 ZBED1	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		5660	7337
HPRD ID		01460	03375
Ensembl ID		ENSG00000197746	ENSG00000114062
Uniprot IDs		P07602	Q05086 Q9BUI6 Q9H2G0
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ	1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Sperm Entry Positive Regulation Of Histone H4-K16 Acetylation Protein Localization Involved In Establishment Of Planar Polarity Intracellular Steroid Hormone Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Cellular Protein Modification Process Protein Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Establishment Of Body Hair Planar Orientation Positive Regulation Of Histone H3-K9 Acetylation Lateral Sprouting Involved In Lung Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Glucosylceramide Catabolic Process Urogenital System Development Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Organ Growth Cellular Response To Tumor Necrosis Factor Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Zygotic Specification Of Dorsal/ventral Axis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Protein Modification By Small Protein Removal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Mesonephros Development Response To Tumor Necrosis Factor Glucosylceramide Metabolic Process Cellular Response To Indole-3-methanol Establishment Of Planar Polarity Of Embryonic Epithelium Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Mesoderm Development Negative Regulation Of Centriole Replication Primary MiRNA Processing Sphingosine Biosynthetic Process Embryo Development Kidney Epithelium Development Dosage Compensation By Inactivation Of X Chromosome Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Sphingoid Biosynthetic Process	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?		ac acinar adenocarcinoma cdx2 cea ck20 ck7 dac debated erg gleason hmwck immunomarkers ki lysozyme morphotypes overlap p16 p504s p63 patchy pax prolactin prostatic prostein psma slides villin	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?