PSAP and CD1B

Number of citations: 0 (PubMedID 14716313)
Data Source: HPRD (in vitro)

		PSAP	CD1B
Name		prosaposin	CD1b molecule
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Space Lysosome Lysosomal Membrane Endosome Golgi Apparatus Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Protein Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Lipopeptide Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib
Pathways		Platelet degranulation Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Glycosphingolipid catabolism	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine	None
Diseases		Krabbe disease; Globoid cell leukodystrophy Gaucher disease Metachromatic leukodystrophy (MLD)	None
GWAS		Asthma (childhood onset) ( 23829686 ) Seasonality and depression ( 30217971 )	No GWAS studies recorded
Interacting Genes		22 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD DYRK1A ERBB2 GBA1 HSPA13 MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 UBE3A USP4 ZBED1	2 interacting genes: B2M PSAP
Entrez ID		5660	910
HPRD ID		01460	01775
Ensembl ID		ENSG00000197746	ENSG00000158485
Uniprot IDs		P07602	P29016
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR 8EQU 9AVS 9AXG	1GZP 1GZQ 1UQS 2H26 3OV6 3T8X 4ONO 5C9J 5L2J 5L2K 5WKE 5WKG 5WKI 5WL1 6CUG 6D64 8DV3 8DV4 8GLE 8GLF 8GLG 8GLH 8GLI 8ZOX
GO Terms Enriched among Interactors		Macromolecule Metabolic Process Protein Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Post-translational Protein Modification Protein Modification Process I-SMAD Binding Protein Modification By Small Protein Conjugation Antigen Processing And Presentation Aspartic-type Endopeptidase Activity Lysosome Response To Thyroid Hormone Transcription Coactivator Activity Endosome Membrane SMAD Protein Signal Transduction Receptor Recycling Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Protein-containing Complex Assembly	Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Cellular Response To Iron(III) Ion Negative Regulation Of Forebrain Neuron Differentiation Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Negative Regulation Of Iron Ion Transport Ganglioside GT1b Binding Ganglioside GM1 Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Regulation Of Forebrain Neuron Differentiation Response To Iron(III) Ion Cellular Response To Nicotine HFE-transferrin Receptor Complex Regulation Of Iron Ion Transport MHC Class I Peptide Loading Complex Lysosomal Membrane Cellular Response To Iron Ion Early Endosome Lumen Identical Protein Binding Cellular Heat Acclimation Glycolipid Transport MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Epithelial Cell Differentiation Involved In Prostate Gland Development Prostate Gland Growth Transferrin Transport Peptide Antigen Assembly With MHC Class II Protein Complex Cell Differentiation Axonal Transport Of Mitochondrion Positive Regulation Of Cellular Senescence MHC Class II Protein Complex Ceramide Transport T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Endogenous Antigen Multicellular Organismal-level Iron Ion Homeostasis Amyloid Fibril Formation Cellular Developmental Process Protein Homodimerization Activity Protein Refolding Mitochondrion Transport Along Microtubule Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Response To Iron Ion