PSAP and GBA1

Number of citations of the paper that reports this interaction (PubMedID 7613473)
27

Data Source:
HPRD (in vitro)

		PSAP	GBA1
Description		prosaposin	glucosylceramidase beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Space Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Galactosylceramidase Activity Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Beta-glucosidase Activity Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Glucosyltransferase Activity Steryl-beta-glucosidase Activity
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Mitophagy Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Metabolic Process Glucosylceramide Catabolic Process Autophagy Mitochondrion Organization Lysosome Organization Central Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Negative Regulation Of Macromolecule Metabolic Process Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Respiratory Electron Transport Chain Termination Of Signal Transduction Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Response To Testosterone Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Nervous System Process Neuromuscular Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Neuron Apoptotic Process Establishment Of Skin Barrier Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Skin Epidermis Development Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neuronal Action Potential Autophagosome Organization Positive Regulation Of Type 2 Mitophagy Lysosomal Protein Catabolic Process Regulation Of Lysosomal Protein Catabolic Process
Pathways		Platelet degranulation Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Glycosphingolipid catabolism	Association of TriC/CCT with target proteins during biosynthesis Glycosphingolipid catabolism
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine	scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases		Krabbe disease; Globoid cell leukodystrophy Gaucher disease Metachromatic leukodystrophy (MLD)	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Gaucher disease
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)
Interacting Genes		22 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD DYRK1A ERBB2 GBA1 HSPA13 MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 UBE3A USP4 ZBED1	5 interacting genes: NEDD4 OGT PSAP SNCA TRIP12
Entrez ID		5660	2629
HPRD ID		01460	06973
Ensembl ID		ENSG00000197746	ENSG00000177628
Uniprot IDs		P07602	A0A068F658 B7Z6S9 P04062
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR 8EQU 9AVS 9AXG	1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6T13 6TJJ 6TJK 6TJQ 6TN1 6YTP 6YTR 6YUT 6YV3 6Z39 6Z3I 7NWV 8AWK 8AWR 8AX3 8P3E 8P41 9F9Z 9FA3 9FA6 9FAD 9FAL 9FAY 9FAZ 9FB2 9FDI
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Post-translational Protein Modification Protein Modification Process I-SMAD Binding Protein Modification By Small Protein Conjugation Antigen Processing And Presentation Aspartic-type Endopeptidase Activity Lysosome Response To Thyroid Hormone Transcription Coactivator Activity Endosome Membrane SMAD Protein Signal Transduction Receptor Recycling Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Protein-containing Complex Assembly	Protein Domain Specific Binding Protein Localization To Lysosome Receptor Internalization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Autophagy Formation Of Structure Involved In A Symbiotic Process Regulation Of Lipid Metabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Lipid Binding Positive Regulation Of Beta-galactosidase Activity Enzyme Activator Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Channel Inhibitor Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Heterochromatin Boundary Formation Phospholipid Binding Negative Regulation Of Protein Catabolic Process Lysosomal Transport Phosphothreonine Residue Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Negative Regulation Of Serotonin Uptake Negative Regulation Of Protein-containing Complex Assembly Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity Perinuclear Region Of Cytoplasm Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Vacuolar Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Periphery Regulation Of Serotonin Uptake Cell Cortex Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein-containing Complex
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