PSAP and CELSR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSAP	CELSR1
Description		prosaposin	cadherin EGF LAG seven-pass G-type receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome	Nucleoplasm Plasma Membrane Adherens Junction Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Nervous System Development Axonogenesis Central Nervous System Development Regulation Of Actin Cytoskeleton Organization Establishment Of Planar Polarity Of Embryonic Epithelium Cell-cell Adhesion Mediated By Cadherin Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Protein Localization Involved In Establishment Of Planar Polarity
Pathways		Platelet degranulation Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases		Krabbe disease; Globoid cell leukodystrophy Gaucher disease Metachromatic leukodystrophy (MLD)
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Left–right brain asymmetry ( 33723403) Urate levels in obese individuals ( 25811787)
Interacting Genes		22 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD DYRK1A ERBB2 GBA1 HSPA13 MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 UBE3A USP4 ZBED1	1 interacting genes: PSAP
Entrez ID		5660	9620
HPRD ID		01460	05160
Ensembl ID		ENSG00000197746	ENSG00000075275
Uniprot IDs		P07602	A0A6I8PRU0 Q9NYQ6
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR 8EQU 9AVS 9AXG	7SZ8 8D40
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Post-translational Protein Modification Protein Modification Process I-SMAD Binding Protein Modification By Small Protein Conjugation Antigen Processing And Presentation Aspartic-type Endopeptidase Activity Lysosome Response To Thyroid Hormone Transcription Coactivator Activity Endosome Membrane SMAD Protein Signal Transduction Receptor Recycling Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Protein-containing Complex Assembly	Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Glycolipid Transport Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Ceramide Transport Cell Aggregation Cartilage Condensation Fibroblast Growth Factor Receptor Binding Myoblast Differentiation Azurophil Granule Membrane Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Extracellular Space Carbohydrate Derivative Transport Enzyme Activator Activity Scaffold Protein Binding Positive Regulation Of Cell Division Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Lysosomal Lumen
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