PSAP and PEX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSAP	PEX5
Description		prosaposin	peroxisomal biogenesis factor 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome	Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein-containing Complex
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein Carrier Chaperone
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Very Long-chain Fatty Acid Metabolic Process Pexophagy Neuron Migration Protein Monoubiquitination Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Beta-oxidation Mitochondrion Organization Mitochondrial Membrane Organization Endoplasmic Reticulum Organization Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Cerebral Cortex Cell Migration Cerebral Cortex Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Positive Regulation Of Multicellular Organism Growth Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Membrane Cell Development Neuromuscular Process Protein Tetramerization
Pathways		Platelet degranulation Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Glycosphingolipid catabolism	Pexophagy
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases		Krabbe disease; Globoid cell leukodystrophy Gaucher disease Metachromatic leukodystrophy (MLD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)	IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD DYRK1A ERBB2 GBA1 HSPA13 MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 UBE3A USP4 ZBED1	77 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 NUFIP2 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772
Entrez ID		5660	5830
HPRD ID		01460	02684
Ensembl ID		ENSG00000197746	ENSG00000139197
Uniprot IDs		P07602	A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR 8EQU 9AVS 9AXG	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO 7Z0K 9GAG
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Protein Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Post-translational Protein Modification Protein Modification Process I-SMAD Binding Protein Modification By Small Protein Conjugation Antigen Processing And Presentation Aspartic-type Endopeptidase Activity Lysosome Response To Thyroid Hormone Transcription Coactivator Activity Endosome Membrane SMAD Protein Signal Transduction Receptor Recycling Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Protein-containing Complex Assembly	Peroxisome Peroxisomal Matrix Carboxylic Acid Catabolic Process Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Carboxylic Acid Metabolic Process Fatty Acid Catabolic Process Organic Acid Metabolic Process Lipid Oxidation Peroxisome Organization Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Peroxisomal Membrane Transport Peroxisomal Membrane Lipid Modification Protein Import Into Peroxisome Matrix, Receptor Recycling Intracellular Protein Transmembrane Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Small Molecule Metabolic Process Lipid Metabolic Process Protein Unfolding Lipid Catabolic Process Protein Transmembrane Transport Catabolic Process Fatty Acid Beta-oxidation Receptor Recycling Protein Targeting To Peroxisome Cytosol Establishment Of Protein Localization To Organelle Receptor Metabolic Process Sulfur Compound Metabolic Process Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Import Into Peroxisome Matrix, Substrate Release Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Oxidoreductase Activity Protein Localization To Organelle Purine-containing Compound Metabolic Process Small Molecule Biosynthetic Process Peroxisomal Importomer Complex Malonyl-CoA Catabolic Process Protein Transmembrane Transporter Activity Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Telomere Assembly Organophosphate Metabolic Process
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