FOLR1 and IRAK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FOLR1	IRAK3
Gene Name		folate receptor 1 (adult)	interleukin-1 receptor-associated kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Interleukin-1 Receptor Complex
	Molecular Function	Receptor Activity Folic Acid Binding Folic Acid Transporter Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Receptor-mediated Endocytosis Folic Acid Transport Folic Acid Metabolic Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways			Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Cytokine Signaling in Immune system Interleukin-1 signaling Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CUL3 IRAK3 LYN NCAPH2	17 interactors: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		2348	11213
HPRD ID		00638	05123
Ensembl ID		ENSG00000110195	ENSG00000090376
Uniprot IDs		P15328	Q9Y616
PDB IDs		4KM6 4KM7 4KMX 4LRH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Mast Cell Proliferation Negative Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Protein Autophosphorylation Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Trophectodermal Cellular Morphogenesis Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Macrophage Cytokine Production Regulation Of Phosphorylation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of MAP Kinase Activity Immune Response-inhibiting Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mast Cell Proliferation Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Organelle Localization	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Lipid Regulation Of Innate Immune Response Response To Lipopolysaccharide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Molecule Of Bacterial Origin Toll-like Receptor 9 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 JNK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Lipid Regulation Of Immune Response Regulation Of Immune System Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Immune Response Response To Cytokine Response To Other Organism Response To Biotic Stimulus Cellular Response To Interleukin-1 Inflammatory Response Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Intersection) ?