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MAPK3 and MAPK8
Number of citations of the paper that reports this interaction (PubMedID
15778365
)
0
Data Source:
HPRD
(in vivo)
MAPK3
MAPK8
Description
mitogen-activated protein kinase 3
mitogen-activated protein kinase 8
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Cilium
Microtubule Cytoskeleton
Membrane
Pseudopodium
Ciliary Basal Body
Anchoring Junction
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axon
Synapse
Basal Dendrite
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Phosphatase Binding
Identical Protein Binding
Protein Serine Kinase Activity
DNA-binding Transcription Factor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Phosphatase Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
Biological Process
Autophagosome Assembly
MAPK Cascade
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA-templated Transcription
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Macrophage Chemotaxis
Neural Crest Cell Development
Schwann Cell Development
Phosphorylation
Sensory Perception Of Pain
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Nutrient Levels
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Lipopolysaccharide
Regulation Of Stress-activated MAPK Cascade
Cellular Response To Amino Acid Starvation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
ERBB2-ERBB3 Signaling Pathway
TORC1 Signaling
Outer Ear Morphogenesis
Myelination
Glucose Homeostasis
Signal Transduction In Response To DNA Damage
Response To Exogenous DsRNA
Positive Regulation Of Transcription By RNA Polymerase II
Insulin-like Growth Factor Receptor Signaling Pathway
Thymus Development
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Negative Regulation Of T Cell Activation
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Interleukin-34-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Negative Regulation Of Cholesterol Efflux
Xenophagy
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Neuroinflammatory Response
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
MAPK Cascade
Double-strand Break Repair
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Cyclase Activity
Positive Regulation Of Cell Killing
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
NLRP3 Inflammasome Complex Assembly
Rhythmic Process
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
MRNA Destabilization
Protein Poly-ADP-ribosylation
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Senescence
Energy Homeostasis
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Localization To Site Of Double-strand Break
Pathways
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Signaling by NODAL
Spry regulation of FGF signaling
Signaling by Activin
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Interferon gamma signaling
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Nuclear events stimulated by ALK signaling in cancer
IFNG signaling activates MAPKs
Negative Regulation of CDH1 Gene Transcription
NPAS4 regulates expression of target genes
NPAS4 regulates expression of target genes
Growth hormone receptor signaling
Signaling by LTK in cancer
Transcriptional and post-translational regulation of MITF-M expression and activity
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Drugs
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Colforsin
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
24076602
31604244
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
25056061
28991256
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Opioid dependence (time to event) (
34124712
)
Refractive error (
32231278
)
Interacting Genes
194 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BTG2
BUB1
C1QBP
CALD1
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
CYLD
DAPK1
DCC
DCP1A
DEPTOR
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HES6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDCD1
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TPD52
TRIM15
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
140 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
ATM
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
H2AX
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
METTL3
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCA
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
Entrez ID
5595
5599
HPRD ID
03479
03100
Ensembl ID
ENSG00000102882
ENSG00000107643
Uniprot IDs
L7RXH5
P27361
Q9BWJ1
A1L4K2
P45983
PDB IDs
2ZOQ
4QTB
6GES
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
6ZR5
8PT8
8PT9
8PTA
8R5E
8X5M
9FT9
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signaling Cassette
Regulation Of Apoptotic Process
Regulation Of Primary Metabolic Process
MAPK Cascade
Regulation Of Cell Differentiation
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Developmental Process
Cellular Developmental Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Developmental Process
Positive Regulation Of DNA-templated Transcription
Cellular Response To Oxygen-containing Compound
Regulation Of MAPK Cascade
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Development
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Communication
Negative Regulation Of Signal Transduction
Regulation Of RNA Biosynthetic Process
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Response To Lipid
Negative Regulation Of Multicellular Organismal Process
Regulation Of DNA-templated Transcription
Regulation Of Cell Population Proliferation
Intracellular Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Signal Transduction
MAPK Cascade
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Stress
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Cellular Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Regulation Of Cell Communication
Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Hormone
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Cell Death
Regulation Of Cell Differentiation
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