MAPK3 and HDAC4

Number of citations of the paper that reports this interaction (PMID 11114188)
17

Data Source:
HPRD (in vitro)

		MAPK3	HDAC4
Gene Name		mitogen-activated protein kinase 3	histone deacetylase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Cytosol Cytoskeleton Caveola Focal Adhesion Microtubule Cytoskeleton Pseudopodium Extracellular Vesicular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Transcriptional Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin
	Molecular Function	Phosphotyrosine Binding MAP Kinase Activity Protein Binding ATP Binding Phosphatase Binding	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Gene Expression Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Platelet Activation BMP Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat Positive Regulation Of Histone Acetylation TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Regulation Of Cellular Response To Heat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Development Chromatin Remodeling Transcription, DNA-templated Inflammatory Response Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Histone Deacetylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Signaling by FGFR in disease RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Cellular Senescence ERKs are inactivated Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Fcgamma receptor (FCGR) dependent phagocytosis SHC-mediated signalling Regulation of actin dynamics for phagocytic cup formation TRIF-mediated TLR3/TLR4 signaling ERK1 activation Senescence-Associated Secretory Phenotype (SASP) ERK1 activation Signaling by VEGF Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling L1CAM interactions Oncogene Induced Senescence VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor ERKs are inactivated Signal transduction by L1 Insulin receptor signalling cascade ISG15 antiviral mechanism Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR Thrombin signalling through proteinase activated receptors (PARs) ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Growth hormone receptor signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade RNA Polymerase I Promoter Clearance IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Advanced glycosylation endproduct receptor signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade RNA Polymerase I Transcription SHC-mediated signalling Cytokine Signaling in Immune system Cellular response to heat stress Regulation of HSF1-mediated heat shock response NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Oxidative Stress Induced Senescence RNA Polymerase I Promoter Opening Nuclear Events (kinase and transcription factor activation)	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs		Sulindac Arsenic trioxide Purvalanol 5-iodotubercidin
Diseases
GWAS		Pubertal anthropometrics ( 23449627)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Male-pattern baldness ( 22693459) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		161 interactors: ADRBK1 AKR1C1 AMOT ARRB1 ATP1A1 BAZ1B BCL2 BCL3 BTBD10 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CEBPB CPXM1 CREBBP CREM CRP CUEDC2 DAPK1 DCC DCP1A DHPS DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FCGR2B FKBP2 FOXP2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LYN MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K1 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MBP METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NTRK1 NTRK3 NUP153 NUPL1 PAK2 PDE6G PEA15 PFKFB1 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA6 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SP1 SPIB SREBF1 SREBF2 STAR STAT3 STAT5A STMN1 STMN2 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBTF VDR VPS52 ZC3HC1 ZNF219 ZNF7	89 interactors: ACTA1 ANKRA2 ANKRD11 APP AR ATF3 ATRX BCL6 BCOR BRMS1 CACNA1C CAMK2D CAMK4 CBX5 CCDC136 CDKN1A CDR2 CEBPD CIITA CSRP3 CTBP1 EFEMP2 ESR1 GATA1 GCM1 GNB1 GOLGA2 GSK3B HDAC3 HDAC7 HDAC9 HNF4A IFRD1 IKZF2 JDP2 KRT31 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBIE NPPB NR1H2 NR2C1 NR2C2 NUP155 PNMA1 PPARD PPARG PPP2R4 RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SUMO1 SUMO2 SYK TNFRSF14 UBE2I YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZNF354A
Entrez ID		5595	9759
HPRD ID		03479	05610
Ensembl ID		ENSG00000102882	ENSG00000068024
Uniprot IDs		L7RXH5 P27361 Q9BWJ1	B7Z8G5 P56524 Q86YH7
PDB IDs		2ZOQ	2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Response To Growth Factor Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cell Communication Signaling Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Abiotic Stimulus Regulation Of Metabolic Process Signal Transduction Intracellular Signal Transduction Multicellular Organismal Development Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Cellular Process Anatomical Structure Development Response To Stress Regulation Of MAPK Cascade Positive Regulation Of Gene Expression Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Organ Development Neurotrophin Signaling Pathway System Development Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signal Transduction By Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Response To Lipid Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Hormone Regulation Of Cell Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Biosynthetic Process Nitrogen Compound Metabolic Process Anatomical Structure Development System Development Cell Differentiation Developmental Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development DNA-templated Transcription, Initiation Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Lipid Regulation Of Cellular Localization
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	300mg 50mg ameliorated ameliorates ctgf dawley deacetylases dn emphasize fibrogenesis fibronectin fibrosis fibrotic hdacs histology icam microscope migraine myofibroblast nephropathy profibrotic renoprotective route sma sprague stz valproic vpa
Tagcloud (Difference) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	300mg 50mg ameliorated ameliorates ctgf dawley deacetylases dn emphasize fibrogenesis fibronectin fibrosis fibrotic hdacs histology icam microscope migraine myofibroblast nephropathy profibrotic renoprotective route sma sprague stz valproic vpa
Tagcloud (Intersection) ?