MAPK3 and PTPN11

Number of citations of the paper that reports this interaction (PMID 8197172)
7

Data Source:
HPRD (in vitro)

		MAPK3	PTPN11
Gene Name		mitogen-activated protein kinase 3	protein tyrosine phosphatase, non-receptor type 11
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Cytosol Cytoskeleton Caveola Focal Adhesion Microtubule Cytoskeleton Pseudopodium Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Protein Complex
	Molecular Function	Phosphotyrosine Binding MAP Kinase Activity Protein Binding ATP Binding Phosphatase Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding D1 Dopamine Receptor Binding Phospholipase Binding Insulin Receptor Substrate Binding Peptide Hormone Receptor Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Gene Expression Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Platelet Activation BMP Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat Positive Regulation Of Histone Acetylation TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Regulation Of Cellular Response To Heat Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding	DNA Damage Checkpoint Activation Of MAPK Activity Triglyceride Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Brain Development Heart Development Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Adhesion Mediated By Integrin Organ Growth Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Atrioventricular Canal Development Fc-epsilon Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Multicellular Organism Growth Hormone Metabolic Process Glucose Homeostasis Innate Immune Response Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion Regulation Of Protein Export From Nucleus Positive Regulation Of Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Multicellular Organismal Reproductive Process Genitalia Development Inner Ear Development Leukocyte Migration Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Face Morphogenesis Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Signaling by FGFR in disease RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Cellular Senescence ERKs are inactivated Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Fcgamma receptor (FCGR) dependent phagocytosis SHC-mediated signalling Regulation of actin dynamics for phagocytic cup formation TRIF-mediated TLR3/TLR4 signaling ERK1 activation Senescence-Associated Secretory Phenotype (SASP) ERK1 activation Signaling by VEGF Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling L1CAM interactions Oncogene Induced Senescence VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor ERKs are inactivated Signal transduction by L1 Insulin receptor signalling cascade ISG15 antiviral mechanism Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR Thrombin signalling through proteinase activated receptors (PARs) ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Growth hormone receptor signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade RNA Polymerase I Promoter Clearance IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Advanced glycosylation endproduct receptor signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade RNA Polymerase I Transcription SHC-mediated signalling Cytokine Signaling in Immune system Cellular response to heat stress Regulation of HSF1-mediated heat shock response NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Oxidative Stress Induced Senescence RNA Polymerase I Promoter Opening Nuclear Events (kinase and transcription factor activation)	Signaling by FGFR in disease Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Interferon gamma signaling Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling PI3K Cascade TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation Spry regulation of FGF signaling Constitutive PI3K/AKT Signaling in Cancer Platelet sensitization by LDL Signaling by VEGF Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction Interleukin-2 signaling PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation PI3K events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Netrin-1 signaling RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Tie2 Signaling PECAM1 interactions Signaling by FGFR ARMS-mediated activation Nuclear signaling by ERBB4 Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PD-1 signaling PI3K Cascade Signaling by the B Cell Receptor (BCR) Signaling by GPCR FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling PI-3K cascade Toll Like Receptor 9 (TLR9) Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling GAB1 signalosome GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signal regulatory protein (SIRP) family interactions Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Platelet homeostasis Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Costimulation by the CD28 family ERK activation PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell surface interactions at the vascular wall ERK2 activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade ERK2 activation Regulation of IFNG signaling
Drugs		Sulindac Arsenic trioxide Purvalanol 5-iodotubercidin	Dodecane-Trimethylamine
Diseases
GWAS		Pubertal anthropometrics ( 23449627)	Blood pressure ( 21572416) Hematological parameters ( 19820697) Hypothyroidism ( 22493691) Platelet counts ( 22139419) Retinal vascular caliber ( 21060863) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 17554300) Urate levels ( 23263486)
Protein-Protein Interactions		161 interactors: ADRBK1 AKR1C1 AMOT ARRB1 ATP1A1 BAZ1B BCL2 BCL3 BTBD10 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CEBPB CPXM1 CREBBP CREM CRP CUEDC2 DAPK1 DCC DCP1A DHPS DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FCGR2B FKBP2 FOXP2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LYN MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K1 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MBP METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NTRK1 NTRK3 NUP153 NUPL1 PAK2 PDE6G PEA15 PFKFB1 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA6 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SP1 SPIB SREBF1 SREBF2 STAR STAT3 STAT5A STMN1 STMN2 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBTF VDR VPS52 ZC3HC1 ZNF219 ZNF7	114 interactors: ACTN4 ARHGAP1 AXL BCR BDKRB2 BTLA C6orf25 CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTLA4 CXCR4 DAB1 DDR1 EGFR EPHA2 EPOR ERBB2 FCRL3 FLT1 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GRB2 GRIN2B HNRNPU IFNAR1 IFNGR1 IGF1R IL4R IL6ST INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 MAP3K4 MAP3K5 MAPK3 MET MPL MPZL1 MS4A2 MVP NEDD9 NTRK1 NTRK2 PAG1 PDGFRA PDGFRB PECAM1 PIK3CG PIK3R1 PILRA PILRB PLCG1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTPN6 PXN RET ROS1 RPIA SELE SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SOCS3 SOS1 SPRY2 SRC STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TNFRSF1A TREML1 TRIM32
Entrez ID		5595	5781
HPRD ID		03479	01470
Ensembl ID		ENSG00000102882	ENSG00000179295
Uniprot IDs		L7RXH5 P27361 Q9BWJ1	Q06124
PDB IDs		2ZOQ	2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 4DGP 4DGX 4GWF 4H1O 4H34 4JE4
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Response To Growth Factor Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cell Communication Signaling Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Response To Abiotic Stimulus Regulation Of Metabolic Process Signal Transduction Intracellular Signal Transduction Multicellular Organismal Development Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Cellular Process Anatomical Structure Development Response To Stress Regulation Of MAPK Cascade Positive Regulation Of Gene Expression Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Organ Development Neurotrophin Signaling Pathway System Development Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Signal Transduction By Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Response To Lipid Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Hormone Regulation Of Cell Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Response To Organic Substance Immune System Process Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Organic Substance Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation ERBB Signaling Pathway Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Response To Growth Factor Regulation Of Immune Response Positive Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Growth Hormone Receptor Signaling Pathway Defense Response Regulation Of Protein Phosphorylation Protein Autophosphorylation Cellular Response To Growth Hormone Stimulus Cell Migration Regulation Of Body Fluid Levels Positive Regulation Of MAPK Cascade Response To Cytokine Response To Stress Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Cell Motility Positive Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Protein Modification Process Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	absolute case cases count died eleven female indispensable interval jmml juvenile male median monocytes mutation myelomonocytic observation obviously onset peripheral platelet plt progressive ras retrospectively slow sure wbc white
Tagcloud (Difference) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	absolute case cases count died eleven female indispensable interval jmml juvenile male median monocytes mutation myelomonocytic observation obviously onset peripheral platelet plt progressive ras retrospectively slow sure wbc white
Tagcloud (Intersection) ?