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MAPK3 and RXRA
Number of citations of the paper that reports this interaction (PubMedID
20371703
)
45
Data Source:
BioGRID
(enzymatic study)
MAPK3
RXRA
Description
mitogen-activated protein kinase 3
retinoid X receptor alpha
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Cilium
Microtubule Cytoskeleton
Membrane
Pseudopodium
Ciliary Basal Body
Anchoring Junction
Glutamatergic Synapse
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Phosphatase Binding
Identical Protein Binding
Protein Serine Kinase Activity
DNA-binding Transcription Factor Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
Retinoic Acid Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Enzyme Binding
Peptide Binding
Identical Protein Binding
Nuclear Vitamin D Receptor Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
Metal Ion Binding
DNA Binding Domain Binding
LBD Domain Binding
Vitamin D Response Element Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Autophagosome Assembly
MAPK Cascade
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA-templated Transcription
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Macrophage Chemotaxis
Neural Crest Cell Development
Schwann Cell Development
Phosphorylation
Sensory Perception Of Pain
Regulation Of Ossification
BMP Signaling Pathway
Regulation Of Cellular PH
Thyroid Gland Development
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Nutrient Levels
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Lipopolysaccharide
Regulation Of Stress-activated MAPK Cascade
Cellular Response To Amino Acid Starvation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
ERBB2-ERBB3 Signaling Pathway
TORC1 Signaling
Outer Ear Morphogenesis
Myelination
Glucose Homeostasis
Signal Transduction In Response To DNA Damage
Response To Exogenous DsRNA
Positive Regulation Of Transcription By RNA Polymerase II
Insulin-like Growth Factor Receptor Signaling Pathway
Thymus Development
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Negative Regulation Of T Cell Activation
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Bergmann Glial Cell Differentiation
Face Development
Lung Morphogenesis
Trachea Formation
Cardiac Neural Crest Cell Development Involved In Heart Development
Interleukin-34-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Negative Regulation Of Cholesterol Efflux
Xenophagy
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Neuroinflammatory Response
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Xenophagy
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Nervous System Development
Hormone-mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Cell Differentiation
Monocyte Differentiation
Positive Regulation Of Bone Mineralization
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Lipid Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Cell Maturation
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Low-density Lipoprotein Particle Stimulus
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Positive Regulation Of Lipoprotein Transport
Pathways
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Signaling by NODAL
Spry regulation of FGF signaling
Signaling by Activin
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Interferon gamma signaling
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Nuclear events stimulated by ALK signaling in cancer
IFNG signaling activates MAPKs
Negative Regulation of CDH1 Gene Transcription
NPAS4 regulates expression of target genes
NPAS4 regulates expression of target genes
Growth hormone receptor signaling
Signaling by LTK in cancer
Transcriptional and post-translational regulation of MITF-M expression and activity
BMAL1:CLOCK,NPAS2 activates circadian expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
PPARA activates gene expression
Carnitine shuttle
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Cytoprotection by HMOX1
Heme signaling
TGFBR3 expression
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Sulindac
Acetylsalicylic acid
Minocycline
Arsenic trioxide
Colforsin
Purvalanol
5-iodotubercidin
Seliciclib
Cholecystokinin
Ulixertinib
alpha-Linolenic acid
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Etodolac
Tretinoin
Etretinate
Bezafibrate
Alfacalcidol
Phthalic Acid
Doconexent
Oleic Acid
Arachidonic Acid
EVT-101
3,20-Pregnanedione
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Tributyltin
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Childhood body mass index (
33045005
)
Hodgkin's lymphoma (
30194254
)
Multiple sclerosis (
24076602
31604244
)
Pubertal anthropometrics (
23449627
)
Schizophrenia (
25056061
28991256
29483656
)
Tonsillectomy (
27182965
28928442
)
Waist circumference (
28552196
)
Weight (
28552196
)
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Blood pressure (
24954895
)
Central corneal thickness (
22814818
23493294
28171582
29760442
30894546
31798171
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
HDL cholesterol levels in HIV infection (
33109212
)
Intelligence (
22449649
)
Intraocular pressure (
29617998
)
Keratoconus (
33649486
)
Refractive error (
32231278
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Interacting Genes
194 interacting genes:
AKR1C1
AMOT
ARRB1
ATP1A1
AURKA
BCL2
BCL3
BRAF
BTBD10
BTG2
BUB1
C1QBP
CALD1
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CDC45
CDH1
CDKN2A
CEBPB
CPXM1
CREBBP
CREM
CRP
CTNND1
CUEDC2
CYLD
DAPK1
DCC
DCP1A
DEPTOR
DLC1
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
EGFR
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FBXW7
FCGR2B
FKBP2
FOS
FOXP2
FRS2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GRK2
GTF2I
HDAC4
HDAC6
HES6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
IRS1
ITGAV
ITGB3
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LRRC4
LYN
MAFG
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MAPT
MBP
MED1
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NRAS
NTRK1
NTRK3
NUP153
NUP58
PAK2
PDCD1
PDE6G
PDGFRL
PEA15
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RB1
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SOS1
SOX2
SP1
SPIB
SRC
SREBF1
SREBF2
STAR
STAT3
STAT5A
STK11
STMN1
STMN2
STUB1
SULT4A1
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TPD52
TRIM15
TRIM54
TSC2
TTYH3
UBE4B
UBTF
USP21
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
119 interacting genes:
ACVR1
ACVR1B
ALOX15B
ARID5A
BCL3
BMAL1
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNMT3L
DNTTIP2
EDF1
ESR1
ESRRA
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
KLF5
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A1
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCB1
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBE2I
UBQLN4
UBR5
VDR
ZBTB16
ZNHIT3
Entrez ID
5595
6256
HPRD ID
03479
01577
Ensembl ID
ENSG00000102882
ENSG00000186350
Uniprot IDs
L7RXH5
P27361
Q9BWJ1
A0A5F9ZHH6
F1D8Q5
P19793
Q6P3U7
PDB IDs
2ZOQ
4QTB
6GES
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4CN2
4CN3
4CN5
4CN7
4J5W
4J5X
4K4J
4K6I
4M8E
4M8H
4N5G
4N8R
4NQA
4OC7
4POH
4POJ
4PP3
4PP5
4RFW
4RMC
4RMD
4RME
4ZO1
4ZSH
5EC9
5JI0
5LYQ
5MJ5
5MK4
5MKJ
5MKU
5MMW
5TBP
5UAN
5Z12
5ZQU
6A5Y
6A5Z
6A60
6FBQ
6FBR
6HN6
6JNO
6JNR
6L6K
6LB4
6LB5
6LB6
6SJM
6STI
6XWG
6XWH
7A77
7B88
7B9O
7BK4
7CFO
7NKE
7UW2
7UW4
8HBM
8PP0
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signaling Cassette
Regulation Of Apoptotic Process
Regulation Of Primary Metabolic Process
MAPK Cascade
Regulation Of Cell Differentiation
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Developmental Process
Cellular Developmental Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Developmental Process
Positive Regulation Of DNA-templated Transcription
Cellular Response To Oxygen-containing Compound
Regulation Of MAPK Cascade
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Development
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Communication
Negative Regulation Of Signal Transduction
Regulation Of RNA Biosynthetic Process
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Response To Lipid
Negative Regulation Of Multicellular Organismal Process
Regulation Of DNA-templated Transcription
Regulation Of Cell Population Proliferation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Chromatin
Nuclear Receptor Activity
Nuclear Retinoid X Receptor Binding
Nuclear Receptor-mediated Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Sequence-specific DNA Binding
Nuclear Receptor Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-templated Transcription
Transcription Coactivator Activity
Transcription By RNA Polymerase II
Nuclear Thyroid Hormone Receptor Binding
Transcription Regulator Complex
Nuclear Retinoic Acid Receptor Binding
Intracellular Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
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