MAPK3 and LCK

Number of citations of the paper that reports this interaction (PubMedID 8506364)
27

Data Source:
HPRD (in vitro, in vivo)

		MAPK3	LCK
Description		mitogen-activated protein kinase 3	LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Cilium Microtubule Cytoskeleton Membrane Pseudopodium Ciliary Basal Body Anchoring Junction Glutamatergic Synapse	Pericentriolar Material Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatase Binding Identical Protein Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding ATPase Binding Protein Antigen Binding
	Biological Process	Autophagosome Assembly MAPK Cascade Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA-templated Transcription Protein Phosphorylation Apoptotic Process DNA Damage Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Macrophage Chemotaxis Neural Crest Cell Development Schwann Cell Development Phosphorylation Sensory Perception Of Pain Regulation Of Ossification BMP Signaling Pathway Regulation Of Cellular PH Thyroid Gland Development Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Nutrient Levels Positive Regulation Of Telomere Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of Stress-activated MAPK Cascade Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation ERBB2-ERBB3 Signaling Pathway TORC1 Signaling Outer Ear Morphogenesis Myelination Glucose Homeostasis Signal Transduction In Response To DNA Damage Response To Exogenous DsRNA Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development Modulation Of Chemical Synaptic Transmission Protein Stabilization Negative Regulation Of T Cell Activation Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Cardiac Neural Crest Cell Development Involved In Heart Development Interleukin-34-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Negative Regulation Of Cholesterol Efflux Xenophagy Positive Regulation Of Macrophage Proliferation Positive Regulation Of Neuroinflammatory Response Negative Regulation Of TORC1 Signaling Positive Regulation Of Xenophagy Regulation Of Early Endosome To Late Endosome Transport	Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Intracellular Zinc Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Hemopoiesis Platelet Activation T Cell Differentiation T Cell Costimulation Positive Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation CD27 Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Signaling by NODAL Spry regulation of FGF signaling Signaling by Activin Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Interferon gamma signaling Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Nuclear events stimulated by ALK signaling in cancer IFNG signaling activates MAPKs Negative Regulation of CDH1 Gene Transcription NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Growth hormone receptor signaling Signaling by LTK in cancer Transcriptional and post-translational regulation of MITF-M expression and activity	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Co-inhibition by PD-1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOH GTPase cycle Interleukin-2 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases
Drugs		Sulindac Acetylsalicylic acid Minocycline Arsenic trioxide Colforsin Purvalanol 5-iodotubercidin Seliciclib Cholecystokinin Ulixertinib	Dasatinib AP-22408 Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib Fostamatinib Zanubrutinib Zotiraciclib
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Hodgkin's lymphoma ( 30194254) Multiple sclerosis ( 24076602 31604244) Pubertal anthropometrics ( 23449627) Schizophrenia ( 25056061 28991256 29483656) Tonsillectomy ( 27182965 28928442) Waist circumference ( 28552196) Weight ( 28552196)	Multiple sclerosis ( 31604244)
Interacting Genes		194 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 AURKA BCL2 BCL3 BRAF BTBD10 BTG2 BUB1 C1QBP CALD1 CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CDH1 CDKN2A CEBPB CPXM1 CREBBP CREM CRP CTNND1 CUEDC2 CYLD DAPK1 DCC DCP1A DEPTOR DLC1 DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 EGFR ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HES6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LRRC4 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP MED1 METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NRAS NTRK1 NTRK3 NUP153 NUP58 PAK2 PDCD1 PDE6G PDGFRL PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RB1 RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SRC SREBF1 SREBF2 STAR STAT3 STAT5A STK11 STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TPD52 TRIM15 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7	142 interacting genes: ACP1 ADAM15 AJUBA AR ARHGAP17 ASB9 AXL BCAR1 BRCA1 C1QTNF2 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CIMIP2B CSF2RB CSF3R CSK CSNK2B CTDSP1 CTLA4 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MET MS4A1 MUC1 NEDD9 NFKBIA NFKBID NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 RORB SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOCS1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRIM35 TRPV4 TUB UBAP2 UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70
Entrez ID		5595	3932
HPRD ID		03479	01080
Ensembl ID		ENSG00000102882	ENSG00000182866
Uniprot IDs		L7RXH5 P27361 Q9BWJ1	A0A0S2Z3Y8 E9PJ92 E9PKQ8 P06239 Q573B4
PDB IDs		2ZOQ 4QTB 6GES	1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ 8X2P
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Apoptotic Process Regulation Of Primary Metabolic Process MAPK Cascade Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Developmental Process Positive Regulation Of DNA-templated Transcription Cellular Response To Oxygen-containing Compound Regulation Of MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Development Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of RNA Biosynthetic Process Protein Kinase Activity Regulation Of RNA Metabolic Process Response To Lipid Negative Regulation Of Multicellular Organismal Process Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation	Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Plasma Membrane Intracellular Signal Transduction T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of Immune Response Leukocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune Response Adaptive Immune Response Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signaling Cassette Regulation Of Cell Activation Protein Kinase Binding Regulation Of T Cell Activation T Cell Activation Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Leukocyte Cell-cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction ERBB Signaling Pathway
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