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MAPK3 and TRIM54
Number of citations of the paper that reports this interaction (PMID
24722188
)
1
Data Source:
BioGRID
(two hybrid)
MAPK3
TRIM54
Gene Name
mitogen-activated protein kinase 3
tripartite motif containing 54
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nucleoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Cytosol
Cytoskeleton
Caveola
Focal Adhesion
Microtubule Cytoskeleton
Pseudopodium
Extracellular Vesicular Exosome
Microtubule
Microtubule Associated Complex
Z Disc
Molecular Function
Phosphotyrosine Binding
MAP Kinase Activity
Protein Binding
ATP Binding
Phosphatase Binding
Signal Transducer Activity
Microtubule Binding
Zinc Ion Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Positive Regulation Of Protein Phosphorylation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Induced Protein Phosphorylation
Cell Cycle
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Blood Coagulation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Organ Morphogenesis
Gene Expression
Viral Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Platelet Activation
BMP Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Histone Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Heat
Positive Regulation Of Histone Acetylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cartilage Development
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Interleukin-1-mediated Signaling Pathway
Response To Epidermal Growth Factor
Cellular Response To Mechanical Stimulus
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Regulation Of Cellular Response To Heat
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Apolipoprotein Binding
Microtubule-based Process
Negative Regulation Of Microtubule Depolymerization
Signal Transduction
Multicellular Organismal Development
Cell Differentiation
Pathways
Signaling by FGFR in disease
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Cellular Senescence
ERKs are inactivated
Signaling by EGFRvIII in Cancer
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
SOS-mediated signalling
Fcgamma receptor (FCGR) dependent phagocytosis
SHC-mediated signalling
Regulation of actin dynamics for phagocytic cup formation
TRIF-mediated TLR3/TLR4 signaling
ERK1 activation
Senescence-Associated Secretory Phenotype (SASP)
ERK1 activation
Signaling by VEGF
Downstream signal transduction
Toll Like Receptor 3 (TLR3) Cascade
Signalling to RAS
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Axon guidance
IRS-mediated signalling
L1CAM interactions
Oncogene Induced Senescence
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Innate Immune System
Signaling by Insulin receptor
ERKs are inactivated
Signal transduction by L1
Insulin receptor signalling cascade
ISG15 antiviral mechanism
Interferon Signaling
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
SHC-related events
Signaling by FGFR
Thrombin signalling through proteinase activated receptors (PARs)
ARMS-mediated activation
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Signal attenuation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
ERK/MAPK targets
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by GPCR
FCERI mediated MAPK activation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Negative regulation of FGFR signaling
Signaling by PDGF
DAP12 interactions
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Antiviral mechanism by IFN-stimulated genes
Toll Like Receptor 2 (TLR2) Cascade
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Growth hormone receptor signaling
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
ERK activation
Toll Like Receptor 7/8 (TLR7/8) Cascade
RNA Polymerase I Promoter Clearance
IGF1R signaling cascade
Toll Like Receptor TLR6:TLR2 Cascade
IRS-related events triggered by IGF1R
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
ERK activation
Downstream signaling of activated FGFR
Advanced glycosylation endproduct receptor signaling
Signalling by NGF
SOS-mediated signalling
MAP kinase activation in TLR cascade
RNA Polymerase I Transcription
SHC-mediated signalling
Cytokine Signaling in Immune system
Cellular response to heat stress
Regulation of HSF1-mediated heat shock response
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
SHC1 events in EGFR signaling
FRS2-mediated cascade
IRS-mediated signalling
Oxidative Stress Induced Senescence
RNA Polymerase I Promoter Opening
Nuclear Events (kinase and transcription factor activation)
Drugs
Sulindac
Arsenic trioxide
Purvalanol
5-iodotubercidin
Diseases
GWAS
Pubertal anthropometrics (
23449627
)
Protein-Protein Interactions
161 interactors:
ADRBK1
AKR1C1
AMOT
ARRB1
ATP1A1
BAZ1B
BCL2
BCL3
BTBD10
C1QBP
CASP8
CASP9
CAV1
CCDC6
CDC23
CDC25C
CEBPB
CPXM1
CREBBP
CREM
CRP
CUEDC2
DAPK1
DCC
DCP1A
DHPS
DUSP1
DUSP10
DUSP3
DUSP4
DUSP5
DUSP6
DUSP9
ELK1
ELK4
EPOR
ESR1
ETS1
ETV1
FCGR2B
FKBP2
FOXP2
GAB1
GAB2
GATA1
GATA4
GJA1
GMFB
GTF2I
HDAC4
HDAC6
HIF1A
HMMR
HNF4A
HSF1
HSF4
HSPB8
HTRA2
ID2
IER3
INSR
JUN
JUND
KRT8
KSR2
L3MBTL3
LAMTOR3
LCK
LIPE
LRPAP1
LYN
MAGEA11
MAGED1
MAP2K1
MAP2K2
MAP2K3
MAP3K1
MAP3K14
MAPK14
MAPK8
MAPKAPK2
MBP
METAP2
MKNK1
MYC
MYLK
MYOG
NAB2
NCKIPSD
NGFR
NTRK1
NTRK3
NUP153
NUPL1
PAK2
PDE6G
PEA15
PFKFB1
PFKM
PLAT
PLCB1
PPARA
PPP1CA
PPP2CA
PRKCD
PRKCE
PRKCZ
PTPN11
PTPN5
PTPN7
PTPRE
PTPRR
PXN
RAB4A
RAF1
RALGDS
RCAN1
RET
RNF114
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA6
RPS6KB1
RPTOR
RXRA
SCAND1
SCRIB
SMAD2
SNCG
SORBS3
SP1
SPIB
SREBF1
SREBF2
STAR
STAT3
STAT5A
STMN1
STMN2
SYK
SYN1
SYNE2
TAL1
TAL2
TCF3
TGIF1
TH
TNFSF11
TOP2B
TP53
TRIM54
TSC2
TTYH3
UBTF
VDR
VPS52
ZC3HC1
ZNF219
ZNF7
127 interactors:
ADCY4
ALS2CR11
ARFIP2
ARHGEF5
ATXN3
ATXN3L
ATXN7
BYSL
C12orf49
C1orf109
C1orf216
C1QTNF2
CALM3
CARD9
CCDC102B
CCDC146
CCDC28A
CCDC67
CCDC87
CDK18
CDKN1A
CEP57L1
CHCHD2
CKM
CRADD
CWF19L2
CYTH4
DCUN1D1
DNAL4
DTX2
EHHADH
EIF4E2
ELMO1
ENKD1
EPM2AIP1
EXOSC5
FAM110A
FAM124A
FAM124B
FAM161A
FARS2
FBF1
FLNC
GEM
GMCL1
GTF2IRD2
HAUS1
ING3
INPP5J
IQUB
JOSD1
KDM1A
KIFC3
KLHL38
KPNA2
KRT6A
KRT6B
KRT6C
LENG1
LIN37
LMO2
LNX1
LSM2
MAPK3
MBD3
MCM7
MEAF6
MFAP1
MID2
MYO5B
NGLY1
OSTF1
OTUB1
OTUB2
PIK3R3
PPP1R18
PRF1
RABGEF1
RAD23A
RBM41
RCOR3
RSRC2
SCNM1
SDCBP
SENP3
SH2D1B
SMARCE1
SNF8
SPG21
SSX2IP
STAM
STRA13
TBC1D22B
TCEA2
TCEB3
THOC1
TRIM55
TRIM63
TSHZ3
TTC23
UBE2D3
UBE2I
UBE2U
UCHL1
UCHL3
UCHL5
USHBP1
USP15
USP18
USP2
USP21
USP33
USP4
USP5
USP7
USP8
UTP14C
VPS28
WDR34
WDYHV1
YOD1
ZBTB16
ZGPAT
ZNF250
ZNF417
ZNF572
ZNF587
Entrez ID
5595
57159
HPRD ID
03479
05928
Ensembl ID
ENSG00000102882
ENSG00000138100
Uniprot IDs
L7RXH5
P27361
Q9BWJ1
Q9BYV2
PDB IDs
2ZOQ
3Q1D
Enriched GO Terms of Interacting Partners
?
Response To Organic Substance
Cellular Response To Organic Substance
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Response To Growth Factor
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Regulation Of Signal Transduction
Cell Communication
Signaling
Developmental Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To External Stimulus
Response To Abiotic Stimulus
Regulation Of Metabolic Process
Signal Transduction
Intracellular Signal Transduction
Multicellular Organismal Development
Response To Stimulus
Regulation Of Protein Metabolic Process
Regulation Of Cellular Process
Anatomical Structure Development
Response To Stress
Regulation Of MAPK Cascade
Positive Regulation Of Gene Expression
Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Organ Development
Neurotrophin Signaling Pathway
System Development
Cell Differentiation
Positive Regulation Of Signal Transduction
Regulation Of Phosphorus Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Signal Transduction By Phosphorylation
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Response To Lipid
Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Immune System Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Catalytic Activity
Anatomical Structure Morphogenesis
Response To Hormone
Regulation Of Cell Differentiation
Protein Deubiquitination
Protein Modification By Small Protein Removal
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein K48-linked Deubiquitination
Protein K63-linked Deubiquitination
Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Catabolic Process
Cellular Protein Metabolic Process
Regulation Of Metabolic Process
Cellular Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Organelle Organization
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Histone Deubiquitination
RNA Metabolic Process
Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Cellular Process
Monoubiquitinated Protein Deubiquitination
Histone Modification
Gene Expression
RNA Biosynthetic Process
Chromatin Modification
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Proteolysis
Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Chromatin Organization
Cellular Response To DNA Damage Stimulus
Nitrogen Compound Metabolic Process
Chromosome Organization
Cellular Response To Heat
Negative Regulation Of Cellular Protein Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Tagcloud
?
5p
acvr2a
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
smurf1
systematically
tgfbr3
zfp423
Tagcloud (Difference)
?
5p
acvr2a
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
smurf1
systematically
tgfbr3
zfp423
Tagcloud (Intersection)
?