DMAP1 and TSG101

Number of citations of the paper that reports this interaction (PMID 10888872)
203

Data Source:
HPRD (in vivo, two hybrid)

		DMAP1	TSG101
Gene Name		DNA methyltransferase 1 associated protein 1	tumor susceptibility 101
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm NuA4 Histone Acetyltransferase Complex	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair DNA Methylation Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Growth Positive Regulation Of Transcription Factor Import Into Nucleus Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: DAXX DNMT1 HDAC2 ING1 MNAT1 MRGBP RGS6 TOMM34 TSG101 URI1	69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		55929	7251
HPRD ID		05465	03229
Ensembl ID		ENSG00000178028	ENSG00000074319
Uniprot IDs		B4DQG8 Q9NPF5	Q99816
PDB IDs		3HM5 4IEJ	1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		Chromatin Modification Regulation Of Growth Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Organelle Organization Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Metabolic Process Gene Silencing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Maintenance Of Chromatin Silencing Viral Process Epidermal Cell Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle C-5 Methylation Of Cytosine Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Maintenance Of DNA Methylation Negative Regulation Of MHC Class II Biosynthetic Process Chromatin Remodeling Positive Regulation Of Gene Expression Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter	Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator
Tagcloud ?		1p 1p34 ataxia atm avian cip1 coded dnmt1 doxo doxorubicin heterozygosity histology intriguingly loh mycn myelocytomatosis nb nbs neuroblastoma originates paediatric reagent situations stabilisation sympathetic telangiectasia tumourigenesis unfavourable waf1	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?		1p 1p34 ataxia atm avian cip1 coded dnmt1 doxo doxorubicin heterozygosity histology intriguingly loh mycn myelocytomatosis nb nbs neuroblastoma originates paediatric reagent situations stabilisation sympathetic telangiectasia tumourigenesis unfavourable waf1	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?