DMAP1 and RGS6

Number of citations of the paper that reports this interaction (PMID 14734556)
15

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DMAP1	RGS6
Gene Name		DNA methyltransferase 1 associated protein 1	regulator of G-protein signaling 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm NuA4 Histone Acetyltransferase Complex	Cytoplasm Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding	Signal Transducer Activity GTPase Activator Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair DNA Methylation Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Growth Positive Regulation Of Transcription Factor Import Into Nucleus Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated	G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS			C-reactive protein ( 21300955) Economic and political preferences (environmentalism) ( 22566634) Obesity (extreme) ( 21935397) Smoking cessation ( 20811658)
Protein-Protein Interactions		10 interactors: DAXX DNMT1 HDAC2 ING1 MNAT1 MRGBP RGS6 TOMM34 TSG101 URI1	4 interactors: DMAP1 DNMT1 GNB5 STMN2
Entrez ID		55929	9628
HPRD ID		05465	04871
Ensembl ID		ENSG00000178028	ENSG00000182732
Uniprot IDs		B4DQG8 Q9NPF5	B7Z2A0 B7Z2N1 B7Z7N5 P49758 Q2M3K2
PDB IDs		3HM5 4IEJ	2ES0
Enriched GO Terms of Interacting Partners?		Chromatin Modification Regulation Of Growth Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Organelle Organization Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Metabolic Process Gene Silencing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Maintenance Of Chromatin Silencing Viral Process Epidermal Cell Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle C-5 Methylation Of Cytosine Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Maintenance Of DNA Methylation Negative Regulation Of MHC Class II Biosynthetic Process Chromatin Remodeling Positive Regulation Of Gene Expression Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter	DNA Methylation DNA Modification Regulation Of Gene Expression, Epigenetic C-5 Methylation Of Cytosine Positive Regulation Of Microtubule Depolymerization Negative Regulation Of Voltage-gated Calcium Channel Activity Maintenance Of DNA Methylation Positive Regulation Of Organelle Organization Histone H2A Acetylation DNA Methylation On Cytosine Methylation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Histone Methylation Positive Regulation Of Protein Depolymerization Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Chromatin Modification Regulation Of Histone H3-K4 Methylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Disassembly Rhodopsin Mediated Signaling Pathway Chromatin Organization Negative Regulation Of Microtubule Depolymerization Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Microtubule Polymerization Or Depolymerization Histone H4 Acetylation Regulation Of Organelle Organization Regulation Of Histone Methylation Negative Regulation Of Transmembrane Transport Cellular Response To Amino Acid Stimulus Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Chromosome Organization DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression, Epigenetic
Tagcloud ?		1p 1p34 ataxia atm avian cip1 coded dnmt1 doxo doxorubicin heterozygosity histology intriguingly loh mycn myelocytomatosis nb nbs neuroblastoma originates paediatric reagent situations stabilisation sympathetic telangiectasia tumourigenesis unfavourable waf1	aberrations accelerated anthracene atm augmented carcinogen carcinogenic concurrent confirming countermeasure deficit dimethylbenza dmba ductal genotoxic glands interrogate mammary means mecs obtaining oncogenesis restore suppress suppressive underlie unsurprisingly utilize viable
Tagcloud (Difference) ?		1p 1p34 ataxia avian cip1 coded dnmt1 doxo doxorubicin heterozygosity histology intriguingly loh mycn myelocytomatosis nb nbs neuroblastoma originates paediatric reagent situations stabilisation sympathetic telangiectasia tumourigenesis unfavourable waf1	aberrations accelerated anthracene augmented carcinogen carcinogenic concurrent confirming countermeasure deficit dimethylbenza dmba ductal genotoxic glands interrogate mammary means mecs obtaining oncogenesis restore suppress suppressive underlie unsurprisingly utilize viable
Tagcloud (Intersection) ?		atm