DMAP1 and TCHP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DMAP1	TCHP
Description		DNA methyltransferase 1 associated protein 1	trichoplein keratin filament binding
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol NuA4 Histone Acetyltransferase Complex	Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Desmosome Nuclear Membrane Ciliary Basal Body Keratin Filament Apical Cortex Anchoring Junction Polymeric Cytoskeletal Fiber
	Molecular Function	Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Process Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Apoptotic Process Cell Projection Organization Negative Regulation Of Cell Growth Negative Regulation Of Cilium Assembly
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolite levels (MHPG) ( 23319000) Myocardial infarction ( 30226566) Platelet count ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		41 interacting genes: ARFIP2 BFSP2 BTG3 C1orf216 CCHCR1 CDCA7L CEBPB DAXX DNMT1 DRC4 EXOC8 GINS4 HDAC2 HSF2BP HSPB1 ING1 KRT75 LMNB1 LRSAM1 MIS18A MNAT1 MORF4L1 MRGBP NAP1L2 OGT PFDN1 PIBF1 RGS6 SAAL1 SBK3 SUOX TCEANC TCHP TLK2 TOMM34 TRIM21 TSG101 TSGA10IP TXLNA TXLNB URI1	52 interacting genes: ATPAF2 BCAS2 C21orf91 CBY2 CCDC125 CCDC13 CCDC172 CCDC85B CDR2 CDR2L DMAP1 DYDC1 EIF4ENIF1 HOOK2 ID2 IFFO1 IKZF3 KCTD17 KIAA0753 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT32 KRT34 KRT35 KRT40 KRT5 KRT6A KRT75 KRT8 MIIP MIPOL1 MKRN3 MTUS2 NAB2 NDOR1 NME7 NUP54 PRDM16 PSMB5 RABGEF1 RUSC1 TEX11 TRIM27 TRIM54 USHBP1 VIM WWOX ZIM2
Entrez ID		55929	84260
HPRD ID		05465	14403
Ensembl ID		ENSG00000178028	ENSG00000139437
Uniprot IDs		Q9NPF5	Q9BT92
PDB IDs		3HM5 4IEJ 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9C6N
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance	Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Structural Molecule Activity Cytoskeleton Organization Cytoskeleton Structural Constituent Of Cytoskeleton Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Cell Differentiation Cellular Developmental Process Organelle Organization Protein Binding Scaffold Protein Binding Epidermis Development Cytosol Keratinization Keratin Filament Binding Cell Periphery Developmental Process Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Nuclear Matrix Cornified Envelope Hair Cycle Centrosome Hepatocyte Apoptotic Process
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